In vitro studies of lymphocyte-mediated cytotoxicity may be easily divided into experiments
designed to investigate the lytic activity of primed (presensitized) or nonprimed cells. Studies …

During the past two decades a variety of in vitro procedures has been designed to elucidate
the mechanisms of cellular immunity. The most thoroughly studied systems deal with the …

Inhibition of antibody-dependent cellular cytotoxicity (ADCC) by autologous lymphocytes
was analyzed by using classical techniques for enzyme-substrate interactions. We …

ADCC of lymphocyte suspensions from the spleen, lymph node, and blood in the rat, rabbit,
and guinea pig, was directly correlated with the presence of Fc+ C 3− and indirectly with the …

Human antibody-dependent cellular cytotoxicity (ADCC) mediated by K cells is shown in this
study to be inhibited by autologous lymphocytes. Inhibitor activity resides in a population of …

Publisher Summary Cell-mediated reactions are of major importance for tissue damage in
connection with transplant or tumor rejection, autoimmune disease, or delayed …

Antibody-dependent lymphocytotoxicity (ADL) was studied with human peripheral blood
lymphocytes as effector cells and P815 mouse mastocytoma cells, sensitized with rabbit IgG …

Two classes of lymphocytes are able to exert contact-dependent cytotoxicity: cytotoxic T cells
(CTL) react specifically against target cells presenting processed antigenic peptides on self …

Three classes of cytotoxic lymphocyte are discussed: thymus‐derived T cells, antibody‐
dependent K cells and NK (natural killer) cells. Each of these cytotoxic lymphocytes has …

It is now well established that target cell destruction can be mediated through the interaction
of antibody with normal lymphoid cells as well as through the classic T-cell immunity …