1. In the isolated perfused rat heart, the contractile activity and the oxygen uptake were
varied by altering the aortic perfusion pressure, or by the atrial perfusion technique ('working …

Earlier studies with the perfused rat heart have shown that the rate of glycolysis was
inhibited by the addition of fatt) y acids or ketone bodies to the perfusion medium (l-4). The …

1. The work of the perfused rat heart was acutely increased by raising the aortic pressure in
the Langendorff preparation from 50 to 120mmHg; within 1 min in perfusions with media …

1. The metabolic pattern of [U− 14C] glucose in the isolated rat heart has been studied, with
both retrograde aortic (Langendorff) and atrially (working) perfused preparations in the …

Newsholme & Randle (1961) found that the con-centrations of glucose 6-phosphate and
fructose 6-phosphate were decreased and that of fructose 1, 6-diphosphate was increased …

1. Effects of pH, pCO 2 and bicarbonate on metabolism of [14 C 6] glucose in the isolated
perfused rat heart were studied. 2. 2. With an alkaline extracellular pH, glucose uptake …

Cardiac levels of ATP, glycogen, glucose, glucose 6‐phosphate, fructose 6‐phosphate,
fructose 1, 6‐diphosphate, triose phosphates, glycerol 3‐phosphate, pyruvate, lactate …

The effects of increased cardiac work on glycolysis, the citric acid cycle, and oxidation of fatty
acids were studied in isolated rat hearts. Glycolysis was stimulated by increased work in …

The tissue levels of the glycolytic intermediates and adenine nucleotides were measured in
perfused rat hearts supplied with 20 mm glucose during the transition from aerobiosis to …

Control properties of the glycolytic system in the perfused rat heart have been investigated
with the aid of metabolic inhibitors. Iodoacetamide was used to study the deviations from …