Focusing on adenosine receptors as a potential targeted therapy in human diseases

WI Effendi, T Nagano, K Kobayashi, Y Nishimura - Cells, 2020 - mdpi.com
Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

Adenosine receptors: new opportunities for future drugs

SA Poulsen, RJ Quinn - Bioorganic & medicinal chemistry, 1998 - Elsevier
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Pharmacology of adenosine receptors: the state of the art

PA Borea, S Gessi, S Merighi… - Physiological …, 2018 - journals.physiology.org
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility

PG Baraldi, MA Tabrizi, S Gessi, PA Borea - Chemical reviews, 2008 - ACS Publications
The purine nucleoside adenosine is consensually identified as a major local regulator of
tissue function especially when energy supply fails to meet cellular energy demand. Due to …

The role of receptor structure in determining adenosine receptor activity

ME Olah, GL Stiles - Pharmacology & therapeutics, 2000 - Elsevier
Adenosine produces a wide variety of physiological effects through the activation of cell
surface adenosine receptors (ARs). ARs are members of the G-protein-coupled receptor …

International union of basic and clinical pharmacology. CXII: adenosine receptors: a further update

AP IJzerman, KA Jacobson, CE Müller… - Pharmacological …, 2022 - ASPET
Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

The A3 adenosine receptor: an enigmatic player in cell biology

S Gessi, S Merighi, K Varani, E Leung… - Pharmacology & …, 2008 - Elsevier
Adenosine is a primordial signaling molecule present in every cell of the human body that
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …

Adenosine receptors in health and disease

S Gessi, S Merighi, K Varani, PA Borea - Advances in pharmacology, 2011 - Elsevier
The adenosine receptors A 1, A 2A, A 2B, and A 3 are important and ubiquitous mediators of
cellular signaling, which play vital roles in protecting tissues and organs from damage. In …

Pharmacology and therapeutic applications of A1 adenosine receptor ligands

AK Dhalla, JC Shryock, R Shreeniwas… - Current topics in …, 2003 - ingentaconnect.com
Adenosine's diverse physiological functions are mediated by four subtypes of receptors (A1,
A2A, A2B and A3). The A1 adenosine receptor pharmacology and therapeutic application of …

Adenosine receptor agonists: from basic medicinal chemistry to clinical development

L Yan, JC Burbiel, A Maaß… - Expert opinion on …, 2003 - Taylor & Francis
Adenosine is a physiological nucleoside which acts as an autocoid and activates G protein-
coupled membrane receptors, designated A1, A2A, A2B and A3. Adenosine plays an …