Bipolar depression constitutes a major problem in psychiatry. It correlates with high
suicidality, treatment resistance, chronicity, and poor quality of life. Registered treatment for …

Bipolar depression remains a clinical challenge with a quarter of patients failing to respond
to initial conventional treatments. Although ketamine has been extensively studied in …

Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably unipolar major depressive disorder. However, its efficacy in bipolar depression is …

Background: The therapeutic potential of subanesthetic doses of ketamine appears
promising in unipolar depression; however, its effectiveness in treating bipolar depression …

Bipolar disorder (BD) is a psychiatric illness associated with high morbidity, mortality and
suicide rate. It has neuroprogressive course and a high rate of treatment resistance. Hence …

Depression is the third leading cause of disability in the world. Depressive symptoms may
be reduced within several weeks after the start of conventional antidepressants, but …

Objective: To consolidate the evidence from the literature to evaluate the role of ketamine in
the treatment of bipolar depression. Methods: Major databases, including MEDLINE …

There is an urgent need for more rapidly effective pharmacotherapies for major depressive
disorder and bipolar disorder (BP) that are efficacious and tolerable for depressed patients …

BACKGROUND: Mood disorders are a leading cause of morbidity. Many patients
experience treatment-resistant depression (TRD), and suicide rates are rising. Faster-acting …

Purpose Bipolar disorder is a chronic and recurrent condition often associated with
treatment resistance and suicidality. There is an unmet need for effective treatment in this …