Insufficient radiofrequency ablation promotes hepatocellular carcinoma metastasis through N6‐methyladenosine mRNA methylation‐dependent mechanism
T Su, M Huang, J Liao, S Lin, P Yu, J Yang, Y Cai… - …, 2021 - Wiley Online Library
Background and Aims The dynamic N6‐methyladenosine (m6A) mRNA modification is
essential for acute stress response and cancer progression. Sublethal heat stress from …
essential for acute stress response and cancer progression. Sublethal heat stress from …
[HTML][HTML] Targeting N7-methylguanosine tRNA modification blocks hepatocellular carcinoma metastasis after insufficient radiofrequency ablation
S Zhu, Y Wu, X Zhang, S Peng, H Xiao, S Chen, L Xu… - Molecular Therapy, 2023 - cell.com
Radiofrequency heat ablation is an ideal radical treatment for hepatocellular carcinoma
(HCC). However, insufficient radiofrequency ablation (IRFA) could lead to high recurrence of …
(HCC). However, insufficient radiofrequency ablation (IRFA) could lead to high recurrence of …
[HTML][HTML] Identification and validation of the N6-methyladenosine RNA methylation regulator YTHDF1 as a novel prognostic marker and potential target for …
S Bian, W Ni, M Zhu, Q Song, J Zhang, R Ni… - Frontiers in molecular …, 2020 - frontiersin.org
Purpose: N6-methyladenosine (m6A) RNA methylation has been implicated in various
malignancies. This study aimed to identify the m6A methylation regulator-based prognostic …
malignancies. This study aimed to identify the m6A methylation regulator-based prognostic …
YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation
C Zhang, S Huang, H Zhuang, S Ruan, Z Zhou… - Oncogene, 2020 - nature.com
Abstract N 6-methyladenosine (m6A) RNA methylation contributes to the cancer stem cell
(CSC) phenotype through regulating gene expression. YTHDF2, an m6A reader, was shown …
(CSC) phenotype through regulating gene expression. YTHDF2, an m6A reader, was shown …
[PDF][PDF] RETRACTED: YTHDF1 facilitates the progression of hepatocellular carcinoma by promoting FZD5 mRNA translation in an m6A-dependent manner
X Liu, J Qin, T Gao, C Li, B He, B Pan, X Xu… - … Therapy-Nucleic Acids, 2020 - cell.com
Hepatocellular carcinoma (HCC), one of the most aggressive malignancies, ranks as the
fourth leading cause of cancerrelated deaths worldwide. Emerging evidence indicates that …
fourth leading cause of cancerrelated deaths worldwide. Emerging evidence indicates that …
ALKBH5-modified HMGB1-STING activation contributes to radiation induced liver disease via innate immune response
G Chen, Q Zhao, B Yuan, B Wang, Y Zhang, Z Li… - International Journal of …, 2021 - Elsevier
Purpose Radiation therapy, which is vital for the treatment of primary liver cancer, comes
with unavoidable liver injury, which limits its implementation. N6-methyladenosine (m6A) …
with unavoidable liver injury, which limits its implementation. N6-methyladenosine (m6A) …
[HTML][HTML] m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop
X Liu, M Feng, X Hao, Z Gao, Z Wu, Y Wang, L Du… - Oncogene, 2023 - nature.com
Pancreatic cancer (PC) is the most hypoxic cancer type among solid tumors. The dynamic
changes of RNA N6-methyl-adenosine (m6A) contribute to tumor cells adaption to hypoxic …
changes of RNA N6-methyl-adenosine (m6A) contribute to tumor cells adaption to hypoxic …
YTHDF2 promotes intrahepatic cholangiocarcinoma progression and desensitises cisplatin treatment by increasing CDKN1B mRNA degradation
CS Huang, YQ Zhu, QC Xu, S Chen… - Clinical and …, 2022 - Wiley Online Library
Background Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer with
exceedingly poor prognosis, and chemoresistance is a huge challenge for treatment. N6 …
exceedingly poor prognosis, and chemoresistance is a huge challenge for treatment. N6 …
[HTML][HTML] Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis
L Wang, L Zhu, C Liang, X Huang, Z Liu, J Huo… - Journal of …, 2023 - Elsevier
Background & Aims RNA N 6-methyladenosine (m 6 A) reader protein YTHDF1 has been
implicated in cancer; however, its role in hepatocellular carcinoma (HCC), especially in non …
implicated in cancer; however, its role in hepatocellular carcinoma (HCC), especially in non …
[HTML][HTML] YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition
X Luo, M Cao, F Gao, X He - Experimental hematology & oncology, 2021 - Springer
Abstract Background N 6-methyladenosine (m6A) modification, as the most abundant RNA
modification, widely participates in the physiological process and is involved in multiple …
modification, widely participates in the physiological process and is involved in multiple …
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