In this study, we investigated the effects of subacute agomelatine (40 and 80 mg/kg)
administration on chronic hyperglycemia, metabolic parameters, and pain perception in …

Antidepressants are first-line treatments of neuropathic pain but not all these drugs are really
effective. Agomelatine is an antidepressant with a novel mode of action, acting as an …

This study used various experimental pain methods to investigate the effects of subacute
mianserin administration on diabetes-induced neuropathic pain in rats. The effect of …

The main objective of this study was to investigate potential effectiveness of agomelatine
pretreatment in the prevention of diabetes itself and encephalopathy, with a focus on brain …

Agmatine, an endogenous cationic amine resulting from the decarboxylation of l-arginine,
produces antihyperalgesic and antiallodynic effects in animal models of chronic neuropathic …

Background Current symptomatic treatments for painful peripheral neuropathy in diabetes
have variable efficacy in individual patients. Amongst other chemical transmitters involved in …

Agomelatine, a novel antidepressant exerting its effects through melatonergic and
serotonergic systems, implicated to be effective against pain including neuropathic pain but …

We previously reported that OT-7100 (5-n-butyl-7-(3, 4, 5-trimethoxybenzoylamino) pyrazolo
[1, 5-α] pyrimidine) had antinociceptive potency in various animal models. To further …

Berberine, a chemical found in plants, is used as a supplement for diabetes. This study
aimed to investigate the effects and the underlying molecular regulations of berberine in …

Hyperalgesia and allodynia are among the common manifestations of painful diabetic
neuropathy. Naringenin (NA) has some biological activities, including anti-inflammatory …