Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells
Delivery of nucleic acids, such as mRNA, to immune cells has become a major focus in the
past decade with ionizable lipid nanoparticles (LNPs) emerging as a clinically-validated …
past decade with ionizable lipid nanoparticles (LNPs) emerging as a clinically-validated …
[HTML][HTML] Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery
Lipid nanoparticles (LNPs) have emerged as a viable, clinically-validated platform for the
delivery of mRNA therapeutics. LNPs have been utilized as mRNA delivery systems for …
delivery of mRNA therapeutics. LNPs have been utilized as mRNA delivery systems for …
A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery
GS Naidu, SB Yong, S Ramishetti… - Advanced …, 2023 - Wiley Online Library
Ionizable lipid‐based nanoparticles (LNPs) are the most advanced non‐viral drug delivery
systems for RNA therapeutics and vaccines. However, cell type‐specific, extrahepatic mRNA …
systems for RNA therapeutics and vaccines. However, cell type‐specific, extrahepatic mRNA …
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs
The broad clinical application of mRNA therapeutics has been hampered by a lack of
delivery vehicles that induce protein expression in extrahepatic organs and tissues …
delivery vehicles that induce protein expression in extrahepatic organs and tissues …
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …
diseases and genetic disorders by regulating disease-related gene expression. The …
Chemistry of lipid nanoparticles for RNA delivery
Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery
Stereochemistry can alter small-molecule pharmacokinetics, safety and efficacy. However, it
is unclear whether the stereochemistry of a single compound within a multicomponent …
is unclear whether the stereochemistry of a single compound within a multicomponent …
Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
Endosomal sequestration of lipid-based nanoparticles (LNPs) remains a formidable barrier
to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that …
to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that …
Lipid nanoparticles for cell-specific in vivo targeted delivery of nucleic acids
The last few years have witnessed a great advance in the development of nonviral systems
for in vivo targeted delivery of nucleic acids. Lipid nanoparticles (LNPs) are the most …
for in vivo targeted delivery of nucleic acids. Lipid nanoparticles (LNPs) are the most …
Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy
P Karmacharya, BR Patil, JO Kim - Journal of pharmaceutical investigation, 2022 - Springer
Background Cancer remains a serious health concern worldwide, and different approaches
are being developed for its treatment. The strategy to use the immune system as an …
are being developed for its treatment. The strategy to use the immune system as an …
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