The DNA exonuclease three-prime repair exonuclease 1 (TREX1) is critical for preventing
autoimmunity in mice and humans by degrading endogenous cytosolic DNA, which …

Genomic instability is a hallmark of neoplastic transformation that leads to the accumulation
of mutations, and generates a state of replicative stress in neoplastic cells associated with …

Mutations in the TREX1 3'→ 5'exonuclease are associated with a spectrum of autoimmune
disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS …

A substantial fraction of cancers evade immune detection by silencing Stimulator of
Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation of this program …

Chromosomal instability is a hallmark of human cancer that is associated with aggressive
disease characteristics. Chromosome mis-segregations help fuel natural selection, but they …

The N-terminal domain of Three Prime Repair Exonuclease 1 (TREX1) is catalytically active
and can degrade dsDNA or ssDNA in the cytosol, whereas the C-terminal domain is …

Three-prime repair exonuclease 1 (TREX1) is a major 3′–5′ DNA exonuclease, which
digests cytosolic DNA to avoid inappropriate activation of the innate immune system …

The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive.
We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated …

Radiotherapy is under investigation for its ability to enhance responses to immunotherapy.
However, the mechanisms by which radiation induces anti-tumour T cells remain unclear …

Trex1, a major 3′ DNA exonuclease in mammalian cells, has been thought to act primarily
in DNA replication or repair. Surprisingly, the major phenotype resulting from Trex1 …