Ethnobotany and the role of plant natural products in antibiotic drug discovery
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …
chemical identification and analysis to the assessment of bioactivity. Plant natural products …
Secondary plant metabolites as potent drug candidates against antimicrobial-resistant pathogens
Antibiotic resistance is a major public health threat of the twenty-first century and represents
an important risk to the global economy. Healthcare-associated infections mainly caused by …
an important risk to the global economy. Healthcare-associated infections mainly caused by …
New natural products as new leads for antibacterial drug discovery
DG Brown, T Lister, TL May-Dracka - Bioorganic & medicinal chemistry …, 2014 - Elsevier
Natural products have been a rich source of antibacterial drugs for many decades, but
investments in this area have declined over the past two decades. The purpose of this …
investments in this area have declined over the past two decades. The purpose of this …
[HTML][HTML] Developing new antimicrobial therapies: are synergistic combinations of plant extracts/compounds with conventional antibiotics the solution?
MJ Cheesman, A Ilanko, B Blonk… - Pharmacognosy reviews, 2017 - ncbi.nlm.nih.gov
The discovery of penicillin nearly 90 years ago revolutionized the treatment of bacterial
disease. Since that time, numerous other antibiotics have been discovered from bacteria …
disease. Since that time, numerous other antibiotics have been discovered from bacteria …
Antimicrobial natural products: an update on future antibiotic drug candidates
Covering: 2000 to 2008 Over the last decade, it has become clear that antimicrobial drugs
are losing their effectiveness due to the evolution of pathogen resistance. There is therefore …
are losing their effectiveness due to the evolution of pathogen resistance. There is therefore …
Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants
W Huang, Y Wang, W Tian, X Cui, P Tu, J Li, S Shi… - Antibiotics, 2022 - mdpi.com
The overuse of antibiotics in the past decades has led to the emergence of a large number
of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug …
of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug …
A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery
U Anand, N Jacobo-Herrera, A Altemimi, N Lakhssassi - Metabolites, 2019 - mdpi.com
The war on multidrug resistance (MDR) has resulted in the greatest loss to the world's
economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a …
economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a …
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022
Covering: 2018 to 2022 Antimicrobial resistance (AMR) poses a significant global health
threat. There is a rising demand for innovative drug scaffolds and new targets to combat …
threat. There is a rising demand for innovative drug scaffolds and new targets to combat …
A systematic review of plants with antibacterial activities: A taxonomic and phylogenetic perspective
F Chassagne, T Samarakoon, G Porras… - Frontiers in …, 2021 - frontiersin.org
Background: Antimicrobial resistance represents a serious threat to human health across the
globe. The cost of bringing a new antibiotic from discovery to market is high and return on …
globe. The cost of bringing a new antibiotic from discovery to market is high and return on …
Opportunities for natural products in 21 st century antibiotic discovery
GD Wright - Natural product reports, 2017 - pubs.rsc.org
Natural products and their derivatives are mainstays of our antibiotic drugs, but they are
increasingly in peril. The combination of widespread multidrug resistance in once …
increasingly in peril. The combination of widespread multidrug resistance in once …