Tubulin poisons were first discovered decades ago, but the recent clinical and commercial
success of Taxol® has led to a renaissance in the search for novel mitotic spindle poisons to …

In 2007, over 12-million people were diagnosed with cancer. According to the American
Cancer Society, at least one third of these individuals are not expected to survive the …

Until recently, development of chemotherapeutic agents that target mitosis has centered on
inhibiting the mitotic spindle through interactions with microtubules. The taxanes, while …

Although they have been advocated with an understandable enthusiasm, mitosis-specific
agents such as inhibitors of mitotic kinases and kinesin spindle protein have not been …

(250 words): A diverse group of natural biological compounds bind to microtubules and
suppress microtubule dynamics. Here we review the mechanism of microtubule assembly …

Anti-mitotic therapies in cancer | Journal of Cell Biology | Rockefeller University Press Skip to
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Highly dynamic mitotic-spindle microtubules are among the most successful targets for
anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids …

Interfering with mitosis for cancer treatment is an old concept that has proven highly
successful in the clinics. Microtubule poisons are used to treat patients with different types of …

Microtubule-interacting drugs are important agents in cancer chemotherapy. Some of these
drugs alter microtubule dynamics and engage the cell cycle surveillance mechanisms to …

Mitosis-specific agents have, to date, not been clinically successful. By contrast, microtubule-
targeting agents (MTAs) have a long record of success, usually attributed to the induction of …