The classic concept of self–non-self discrimination by the immune system focused on the
recognition of fragments from proteins presented by classical MHC molecules. However, the …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

The paradigm that T cells recognize peptide antigens presented by major histocompatibility
complex class I and class II molecules has been a guiding principle in the development of …

The CD1 family consists of lipid antigen-presenting molecules, which include group I CD1a,
CD1b, and CD1c and group II CD1d proteins. Topologically, they resemble the classical …

CD I molecules represent a distinct lineage of antigen‐presenting molecules chat are
evolutionarily related to the classical major histocompatility complex (MHC) dass I and class …

The discovery of molecules capable of presenting lipid antigens, the CD1 family, and of the
T cells that recognize them, has opened a new dimensionin our understanding of cell …

Over the past 15 years, investigators have shown that T lymphocytes can recognize not only
peptides in the context of MHC class I and class II molecules but also foreign and self-lipids …

Although there are multiple structures showing how αβ T cell receptors (TCRs) specifically
recognize antigenic peptides bound to the major histocompatibility complex (MHC) …

The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids
and small molecules to T cells. The antigen display platforms in the four CD1 proteins are …

CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate
T cells. Recent crystal structures of CD1 proteins show that their antigen-binding grooves …