Since our proposal of a dualistic model of epithelial ovarian carcinogenesis more than a
decade ago, a large number of molecular and histopathologic studies were published that …

Ovarian epithelial carcinoma (OEC), the most common ovarian malignancy, is a
heterogeneous disease with several histologic subtypes that show characteristic cytogenetic …

The pathogenesis of ovarian carcinoma, the most lethal gynecological malignancy, is
unknown because of the lack of a tumor progression model. Based on a review of recent …

Ovarian cancer is the most lethal gynecologic malignancy. Efforts at early detection and new
therapeutic approaches to reduce mortality have been largely unsuccessful, because the …

Ovarian carcinomas of epithelial type comprise a heterogeneous group of neoplasms, each
with a different underlying pathogenesis and natural behaviour. Accurate classification of …

The accepted view of ovarian carcinogenesis is that carcinoma begins in the ovary,
undergoes progressive" dedifferentiation" from a well to a poorly differentiated tumor, and …

Malignant epithelial tumors (carcinomas) are the most common ovarian cancers and also
the most lethal gynecological malignancies. Based on histopathology and molecular genetic …

Recent morphologic, immunohistochemical, and molecular genetic studies have led to the
development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer …

The pathogenesis of ovarian carcinoma, the most lethal gynecological malignancy, is
unknown because of the lack of a tumor progression model. Based on a review of recent …

The ultimate goal of defining cancer specific precursors is to facilitate early detection and
intervention before the development of invasive malignancy. Unlike other malignancies …