[HTML][HTML] A second WNT for old drugs: drug repositioning against WNT-dependent cancers
K Ahmed, HV Shaw, A Koval, VL Katanaev - Cancers, 2016 - mdpi.com
Aberrant WNT signaling underlies cancerous transformation and growth in many tissues,
such as the colon, breast, liver, and others. Downregulation of the WNT pathway is a desired …
such as the colon, breast, liver, and others. Downregulation of the WNT pathway is a desired …
Mining the Wnt pathway for cancer therapeutics
Aberrant activation of the Wnt pathway is implicated in driving the formation of various
human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway …
human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway …
Targeting the Wnt pathway in cancer: a review of novel therapeutics
R Tabatabai, Y Linhares, D Bolos, M Mita, A Mita - Targeted oncology, 2017 - Springer
Wnt signaling is an evolutionarily conserved pathway that controls cell-to-cell interactions
during embryogenesis. In adults, Wnt signaling plays a role in tissue homeostasis in almost …
during embryogenesis. In adults, Wnt signaling plays a role in tissue homeostasis in almost …
[HTML][HTML] Wnt drug discovery: weaving through the screens, patents and clinical trials
B Lu, BA Green, JM Farr, FCM Lopes, TJ Van Raay - Cancers, 2016 - mdpi.com
The Wnt signaling pathway is intricately involved in many aspects of development and is the
root cause of an increasing number of diseases. For example, colorectal cancer is the …
root cause of an increasing number of diseases. For example, colorectal cancer is the …
Wnt signaling and drug resistance in cancer
Z Zhong, DM Virshup - Molecular pharmacology, 2020 - ASPET
Wnts are secreted proteins that bind to cell surface receptors to activate downstream
signaling cascades. Normal Wnt signaling plays key roles in embryonic development and …
signaling cascades. Normal Wnt signaling plays key roles in embryonic development and …
[HTML][HTML] A new wave of targeting 'undruggable'wnt signaling for cancer therapy: challenges and opportunities
WJ Park, MJ Kim - Cells, 2023 - mdpi.com
Aberrant Wnt signaling activation is frequently observed in many cancers. The mutation
acquisition of Wnt signaling leads to tumorigenesis, whereas the inhibition of Wnt signaling …
acquisition of Wnt signaling leads to tumorigenesis, whereas the inhibition of Wnt signaling …
The Wnt signaling pathway in cancer
Y Duchartre, YM Kim, M Kahn - Critical reviews in oncology/hematology, 2016 - Elsevier
The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …
Wnt pathway modulators in cancer therapeutics: An update on completed and ongoing clinical trials
A Neiheisel, M Kaur, N Ma, P Havard… - … Journal of Cancer, 2022 - Wiley Online Library
Wnt signaling plays an essential role in the initiation and progression of various types of
cancer. Besides, the Wnt pathway components have been established as reliable …
cancer. Besides, the Wnt pathway components have been established as reliable …
[HTML][HTML] Targeting Wnt/β-catenin pathway for drug therapy
C Liu, K Takada, D Zhu - Medicine in Drug Discovery, 2020 - Elsevier
The Wnt/β-catenin signaling pathway, including canonical or noncanonical pathway, is a
highly conserved pathway which can regulate cell proliferation, migration, differentiation …
highly conserved pathway which can regulate cell proliferation, migration, differentiation …
Recent development of Wnt signaling pathway inhibitors for cancer therapeutics
Abstract Purpose of Review Review current understanding of both canonical and non-
canonical Wnt signaling in cancer and provide updated knowledge in current clinical trials of …
canonical Wnt signaling in cancer and provide updated knowledge in current clinical trials of …