Genetic predisposition to pulmonary fibrosis has been confirmed by the discovery of several
gene mutations that cause pulmonary fibrosis. Although genetic sequencing of familial …

Background Idiopathic pulmonary fibrosis, the most common form of idiopathic interstitial
pneumonia, is characterized by progressive, irreversible scarring of the lung parenchyma …

Pulmonary fibrosis comprises a wide range of fibrotic lung diseases with unknown
pathogenesis and poor prognosis. Familial pulmonary fibrosis (FPF) represents a unique …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and ultimately fatal disorder for
which there is no cure. While the disease is by definition idiopathic, accumulating evidence …

There has been increasing recognition that genetic factors play important roles in both
sporadic and familial cases of idiopathic pulmonary fibrosis (IPF)(1). Current data indicate …

Introduction: Many forms of interstitial lung disease (ILD) can progress to extensive fibrosis
and respiratory failure. Idiopathic pulmonary fibrosis (IPF), which generally has a poor …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an increasingly recognized, often fatal lung
disease of unknown etiology. Objectives: The aim of this study was to use whole-exome …

The occurrence of pulmonary fibrosis in numerous individuals from the same family
suggests a genetic cause for the disease. During the last 10 years, mutations involving …

Pulmonary fibrosis refers to the development of diffuse parenchymal abnormalities in the
lung that cause dyspnea, cough, hypoxemia, and impair gas exchange, ultimately leading to …

Patients with familial pulmonary fibrosis represent a subset of patients with pulmonary
fibrosis in whom inherited gene variation predisposes them to disease development. In the …