Abstract Multiple three-dimensional (3D) tumour organoid models assisted by multi-omics
and Artificial Intelligence (AI) have contributed greatly to preclinical drug development and …

Effective predictive biomarkers are needed to enable personalized medicine and increase
treatment efficacy and survival for cancer patients, thereby reducing toxic side effects and …

Simple Summary Currently, organoid research is having a growing impact in oncology.
Tumor organoids, directly derived from patients' specimens, can easily be expanded and …

The emergence of three-dimensional human organoids has opened the door for the
development of patient-derived cancer organoid (PDO) models, which closely recapitulate …

Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …

Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer
biology and develop novel precision medicine therapeutics. However, utilizing TOs for …

Cancer organoids, a three‐dimensional (3D) culture system of cancer cells derived from
tumor tissues, recapitulate physiological structure of the parental tumor. Different tumor …

Patient-derived tumour organoids (PDOs) have revolutionised our understanding of cancer
biology and the applications of personalised therapies. These advancements are principally …

Representative models are needed to screen new therapies for patients with cancer. Cancer
organoids are a leap forward as a culture model that faithfully represents the disease …

Patient-derived cancer organoids have taken a prominent role in pre-clinical and
translational research and have been generated for most common solid tumors. Cancer …