The current report describes a stepwise mechanistic pathway of NLRP3/caspase1/IL-18-
regulated immune responses operational in eosinophilic esophagitis (EoE). We show that …

Several studies have shown that interleukin (IL)‐13 is induced in the esophageal biopsies of
eosinophilic esophagitis (EoE) patients and promotes esophageal eosinophilia in mice …

Elevated levels of interleukin (IL)‐18 have been reported in a number of allergic diseases.
We recently reported that IL‐18 in the blood and IL‐18Rα mRNA in the oesophagus are …

Objective Disruption of the epithelial barrier plays an essential role in developing
eosinophilic oesophagitis (EoE), a disease defined by type 2 helper T cell (Th2)-mediated …

Objective Eosinophilic oesophagitis (EoE) is a chronic inflammatory condition of the
oesophagus with limited treatment options. No previous transgenic model has specifically …

Eosinophilic esophagitis (EoE) is a Th2 cytokine–associated disease characterized by
eosinophil infiltration, epithelial cell hyperplasia, and tissue remodeling. Recent studies …

Eosinophilic esophagitis (EE) is an emerging disease associated with both food and
respiratory allergy characterized by extensive esophageal tissue remodeling and abnormal …

Background Basal zone hyperplasia (BZH) and dilated intercellular spaces (DISs) are
thought to contribute to the clinical manifestations of eosinophilic esophagitis (EoE); …

Eosinophilic esophagitis (EoE) is a chronic type 2 allergic disease, with esophageal tissue
remodeling as the mechanism behind clinical dysphagia and strictures. IL-13 is thought to …

Abstract Background Eosinophilic esophagitis (EoE) is a chronic, food‐driven allergic
disease, characterized by eosinophil‐rich inflammation in the esophagus. The …