Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine
D Martinez, M Slifstein, R Narendran… - …, 2009 - nature.com
The goal of this study was to determine D 1 receptor availability in human cocaine-
dependent (CD) subjects and matched healthy controls (HCs). In addition, the CD subjects …
dependent (CD) subjects and matched healthy controls (HCs). In addition, the CD subjects …
Cocaine self-administration produces a persistent increase in dopamine D2High receptors
Cocaine addicts are reported to have decreased numbers of striatal dopamine D2 receptors.
However, in rodents, repeated cocaine administration consistently produces hypersensitivity …
However, in rodents, repeated cocaine administration consistently produces hypersensitivity …
Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
D Martinez, A Broft, RW Foltin, M Slifstein… - …, 2004 - nature.com
Striatal dopamine D 2 receptors have been implicated in the neurobiology of cocaine
addiction. Previous imaging studies showed reduced striatal D 2 receptor availability in …
addiction. Previous imaging studies showed reduced striatal D 2 receptor availability in …
Dopamine D3 receptor alterations in cocaine-dependent humans imaged with [11C](+) PHNO
D Matuskey, JD Gallezot, B Pittman, W Williams… - Drug and alcohol …, 2014 - Elsevier
Background Evidence from animal models and postmortem human studies points to the
importance of the dopamine D 3 receptor (D 3 R) in cocaine dependence (CD). The …
importance of the dopamine D 3 receptor (D 3 R) in cocaine dependence (CD). The …
Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine …
JL Neisewander, RA Fuchs, LTL Tran-Nguyen… - …, 2004 - nature.com
Previous research suggests that cocaine dysregulates dopamine D 3 receptors. The present
study examined the time course of changes in dopamine D 3 receptor binding after …
study examined the time course of changes in dopamine D 3 receptor binding after …
PET imaging of dopamine D2 receptor and transporter availability during acquisition of cocaine self-administration in rhesus monkeys
Previous studies have demonstrated that cocaine use alters availability of brain dopamine
D2 receptors (D2R) and transporters (DAT). The present study examined the effects of low …
D2 receptors (D2R) and transporters (DAT). The present study examined the effects of low …
Influence of cocaine history on the behavioral effects of dopamine D3 receptor-selective compounds in monkeys
BL Blaylock, RW Gould, A Banala, P Grundt… - …, 2011 - nature.com
Although dopamine D 3 receptors have been associated with cocaine abuse, little is known
about the consequences of chronic cocaine on functional activity of D 3 receptor-preferring …
about the consequences of chronic cocaine on functional activity of D 3 receptor-preferring …
Effects of chronic cocaine and ethanol self‐administration on brain dopamine receptors in a rhesus monkey model of polysubstance abuse
FM Say, AM Tryhus, PM Epperly, SH Nader… - Addiction …, 2022 - Wiley Online Library
Most individuals with cocaine use disorder also use alcohol; however, little is known about
the behavioural and pharmacological mechanisms that promote co‐abuse. For example …
the behavioural and pharmacological mechanisms that promote co‐abuse. For example …
Lower Level of Endogenous Dopamine in Patients With Cocaine Dependence: Findings From PET Imaging of D 2 /D 3 Receptors Following …
D Martinez, K Greene, A Broft, D Kumar… - American Journal of …, 2009 - Am Psychiatric Assoc
Objective: Previous positron emission tomography (PET) imaging studies have
demonstrated that cocaine dependence is associated with a decrease in dopamine type 2 …
demonstrated that cocaine dependence is associated with a decrease in dopamine type 2 …
Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine
Rationale Social rank has been shown to influence dopamine (DA) D 2 receptor function
and vulnerability to cocaine self-administration in cynomolgus monkeys. The present studies …
and vulnerability to cocaine self-administration in cynomolgus monkeys. The present studies …