The goal of this study was to determine D 1 receptor availability in human cocaine-
dependent (CD) subjects and matched healthy controls (HCs). In addition, the CD subjects …

Cocaine addicts are reported to have decreased numbers of striatal dopamine D2 receptors.
However, in rodents, repeated cocaine administration consistently produces hypersensitivity …

Striatal dopamine D 2 receptors have been implicated in the neurobiology of cocaine
addiction. Previous imaging studies showed reduced striatal D 2 receptor availability in …

Background Evidence from animal models and postmortem human studies points to the
importance of the dopamine D 3 receptor (D 3 R) in cocaine dependence (CD). The …

Previous research suggests that cocaine dysregulates dopamine D 3 receptors. The present
study examined the time course of changes in dopamine D 3 receptor binding after …

Previous studies have demonstrated that cocaine use alters availability of brain dopamine
D2 receptors (D2R) and transporters (DAT). The present study examined the effects of low …

Although dopamine D 3 receptors have been associated with cocaine abuse, little is known
about the consequences of chronic cocaine on functional activity of D 3 receptor-preferring …

Most individuals with cocaine use disorder also use alcohol; however, little is known about
the behavioural and pharmacological mechanisms that promote co‐abuse. For example …

Objective: Previous positron emission tomography (PET) imaging studies have
demonstrated that cocaine dependence is associated with a decrease in dopamine type 2 …

Rationale Social rank has been shown to influence dopamine (DA) D 2 receptor function
and vulnerability to cocaine self-administration in cynomolgus monkeys. The present studies …