[HTML][HTML] Development of vericiguat: The first soluble guanylate cyclase (sGC) stimulator launched for heart failure with reduced ejection fraction (HFrEF)

J Xia, N Hui, L Tian, C Liang, J Zhang, J Liu… - Biomedicine & …, 2022 - Elsevier
In recent years, with improvements in treatments for heart failure (HF), the survival period of
patients has been extended. However, the emergence of some patients with repeated …

Vericiguat: a novel soluble guanylate cyclase stimulator for use in patients with heart failure

R Gupta, M Lin, T Maitz, DJ Egeler, A Sood… - Cardiology in …, 2023 - journals.lww.com
Abstract Heart failure (HF) affects 6.2 million Americans and is increasing annually in its
frequency. Treatment of HF has been at the forefront of medical advancements due to the …

Vericiguat for the treatment of heart failure: mechanism of action and pharmacological properties compared with other emerging therapeutic options

JS Hulot, JN Trochu, E Donal, M Galinier… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction The significant morbidity and mortality in patients with heart failure (HF), notably
in the most advanced forms of the disease, justify the need for novel therapeutic options. In …

Vericiguat for the treatment of heart failure with reduced ejection fraction

AK Siddiqi, SJ Greene, M Fudim, RJ Mentz… - Expert Review of …, 2023 - Taylor & Francis
Introduction Despite significant therapeutic advancements in heart failure with reduced
ejection fraction (HFrEF), the residual risk of all-cause mortality and hospitalizations remains …

[HTML][HTML] A systematic review of the effect of vericiguat on patients with heart failure

U Sahana, M Wehland, U Simonsen, H Schulz… - International journal of …, 2023 - mdpi.com
Despite recent advances in heart failure (HF) therapy, the risk of cardiovascular (CV)
mortality, morbidity, and HF hospitalization (HFH) are major challenges in HF treatment. We …

Vericiguat: a new hope for heart failure patients

R Chiles, RA Al-Horani - Cardiovascular Therapeutics, 2022 - Wiley Online Library
Heart failure with reduced ejection fraction (HFrEF) is the inability of the heart to adequately
contract or eject blood. This heart is unable to produce adequate cardiac output to perfuse …

[HTML][HTML] Vericiguat: The Fifth Harmony of heart failure with reduced ejection fraction

L Falco, B Brescia, D Catapano, ML Martucci… - Journal of …, 2023 - mdpi.com
Heart failure with reduced ejection fraction is a chronic and progressive syndrome that
continues to be a substantial financial burden for health systems in Western countries …

Vericiguat: a review in chronic heart failure with reduced ejection fraction

C Kang, YN Lamb - American Journal of Cardiovascular Drugs, 2022 - Springer
Vericiguat (Verquvo®) is the first oral soluble guanylate cyclase (sGC) stimulator to be
approved for the treatment of adults with symptomatic, chronic heart failure with reduced …

[HTML][HTML] Vericiguat in patients with heart failure across the spectrum of left ventricular ejection fraction: a patient-level, pooled meta-analysis of VITALITY-HFpEF and …

C Chen, J Lv, C Liu - Frontiers in Endocrinology, 2024 - frontiersin.org
Vericiguat, the newest soluble guanylate cyclase (sGC) drug, is potentially beneficial in
treating heart failure (HF). However, most studies have only confirmed the significant impact …

Vericiguat: a novel oral soluble guanylate cyclase stimulator for the treatment of heart failure

N Campbell, J Kalabalik-Hoganson… - Annals of …, 2022 - journals.sagepub.com
Objective To review the efficacy and safety of vericiguat indicated to reduce the risk of
cardiovascular death and heart failure (HF) hospitalization following hospitalization or need …