Posttranslational modifications to the intracellular domain of the EGFR are known to regulate
EGFR functions; however, modifications to the extracellular domain and their effects remain …

Key molecular drivers that underlie transformation of colonic epithelium into colorectal
adenocarcinoma (CRC) are well described. However, the mechanisms through which …

Background: Epidermal growth factor receptor (EGFR) promoter methylation may be
responsible for the loss of EGFR expression in neoplastic cells. The primary aim of our study …

Background: High EREG and AREG expression, and left-sided primary tumours are
associated with superior efficacy of anti-epidermal growth factor receptor (EGFR) therapy in …

While multiple post-translational modifications have been reported to regulate the function of
epidermal growth factor receptor (EGFR), the effect of protein methylation on its function has …

Anti-EGFR therapy is among the most promising molecular targeted therapies against
cancer developed in the past decade. However, drug resistance eventually arises in most, if …

The epidermal growth factor receptor (EGFR) is a member of the HER/ERB-B family of
transmembrane receptor kinases. Overexpression of EGFR confers advantages in cell …

The sensitivity of lung cancer to epidermal growth factor receptor (EGFR)-tyrosine kinase
inhibitors (TKIs) has been found to be associated with mutations in the tyrosine kinase …

Epiregulin (EREG) induces cell growth by binding to the epidermal growth factor receptor
(EGFR). Expression of EREG affects sensitivity to cetuximab a chimeric monoclonal antibody …

The epidermal growth factor receptor (EGFR) drives tumor growth in a subset of human
epithelial carcinomas. A crystallographic study by Li et al. in this issue of Cancer Cell …