In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …

In the 1990s, enthusiasm for gene therapy was high, and the cure of human genetic
diseases seemed within reach. However, this excitement halted abruptly when a viral vector …

mRNA is the central molecule of all forms of life. It is generally accepted that current life on
Earth descended from an RNA world. mRNA, after its first therapeutic description in 1992 …

mRNA: Fulfilling the Promise of Gene Therapy: Molecular Therapy Skip to Main Content
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In recent years, the interest in using messenger RNA (mRNA) as a therapeutic means to
tackle different diseases has enormously increased. This holds true not only for numerous …

The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

While active immunization elicits a lasting immune response by the body, passive
immunotherapy transiently equips the body with exogenously generated immunological …

Abstract mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in
accordance with their superiority in expressing all sequence‐known proteins in vivo. In …

The field of gene therapy has evolved over the past two decades after the first introduction of
nucleic acid drugs, such as plasmid DNA (pDNA). With the development of in vitro …

Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …