Simple Summary Neuroblastoma is a pediatric tumor originating from the precursors of
sympathetic nerves. The disease is known for its high heterogeneity. Hence, developing …

Despite advances in cancer therapeutics, particularly in the area of immuno-oncology,
successful treatment of neuroblastoma (NB) remains a challenge. NB is the most common …

Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-
risk neuroblastoma patients have a poor overall survival and account for~ 15% of childhood …

Neuroblastoma is a paediatric cancer of the sympathetic nervous system and the most
common solid tumour of infancy, contributing to 15% of paediatric oncology deaths. Current …

Neuroblastoma is the most common pediatric abdominal solid tumor. This aggressive
embryonal malignancy of neural crest origin has a peak age of onset of 22 months, and …

Introduction Neuroblastoma is a cancer of the sympathetic nervous system that causes up to
15% of cancer-related deaths among children. Among the~ 1,000 newly diagnosed cases …

Neuroblastoma is a childhood tumor derived from precursor or immature cells of the
sympathetic nervous system. Neuroblastomas show a tremendous clinical heterogeneity …

Informative and realistic mouse models of high-risk neuroblastoma are central to
understanding mechanisms of tumour initiation, progression, and metastasis. They also play …

Background Preclinical models of pediatric cancers are essential for testing new
chemotherapeutic combinations for clinical trials. The most widely used genetic model for …

Patient-derived preclinical models are now a core component of cancer research and have
the ability to drastically improve the predictive power of preclinical therapeutic studies …