[HTML][HTML] Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies
Abstract The SARS-CoV-2 Delta variant is currently the dominant circulating strain in the
world. Uncovering the structural basis of the enhanced transmission and altered immune …
world. Uncovering the structural basis of the enhanced transmission and altered immune …
Mutation-induced changes in the receptor-binding interface of the SARS-CoV-2 Delta variant B. 1.617. 2 and implications for immune evasion
Following the initial surges of the Alpha (B. 1.1. 7) and the Beta (B. 1.351) variants, a more
infectious Delta variant (B. 1.617. 2) is now surging, further deepening the health crises …
infectious Delta variant (B. 1.617. 2) is now surging, further deepening the health crises …
[HTML][HTML] Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to
emerge during the global pandemic and may facilitate escape from current antibody …
emerge during the global pandemic and may facilitate escape from current antibody …
[HTML][HTML] Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants
JW Saville, D Mannar, X Zhu, SS Srivastava… - Nature …, 2022 - nature.com
Abstract The Delta and Kappa variants of SARS-CoV-2 co-emerged in India in late 2020,
with the Delta variant underlying the resurgence of COVID-19, even in countries with high …
with the Delta variant underlying the resurgence of COVID-19, even in countries with high …
In vitro data suggest that Indian delta variant B. 1.617 of SARS‐CoV‐2 escapes neutralization by both receptor affinity and immune evasion
G Augusto, MO Mohsen, S Zinkhan, X Liu, M Vogel… - Allergy, 2022 - Wiley Online Library
Background Emerged mutations can be attributed to increased transmissibility of the B.
1.617 and B. 1.36 Indian delta variants of SARS‐CoV‐2, most notably substitutions …
1.617 and B. 1.36 Indian delta variants of SARS‐CoV‐2, most notably substitutions …
[HTML][HTML] Omicron: a heavily mutated SARS-CoV-2 variant exhibits stronger binding to ACE2 and potently escapes approved COVID-19 therapeutic antibodies
The new SARS-CoV-2 variant of concern “Omicron” was recently spotted in South Africa and
spread quickly around the world due to its enhanced transmissibility. The variant became …
spread quickly around the world due to its enhanced transmissibility. The variant became …
[HTML][HTML] S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular …
F Ye, X Lin, Z Chen, F Yang, S Lin, J Yang… - … and Targeted Therapy, 2021 - nature.com
Abstract SARS-CoV-2 recognizes, via its spike receptor-binding domain (S-RBD), human
angiotensin-converting enzyme 2 (ACE2) to initiate infection. Ecto-domain protein of ACE2 …
angiotensin-converting enzyme 2 (ACE2) to initiate infection. Ecto-domain protein of ACE2 …
[HTML][HTML] Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM
The emergence of SARS-CoV-2 Kappa and Beta variants with enhanced transmissibility
and resistance to neutralizing antibodies has created new challenges for the control of the …
and resistance to neutralizing antibodies has created new challenges for the control of the …
[HTML][HTML] Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant
L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch… - Cell, 2020 - cell.com
Summary The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus
worldwide, reaching near fixation in a matter of months. Here we show that D614G was …
worldwide, reaching near fixation in a matter of months. Here we show that D614G was …
[HTML][HTML] Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level
Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …
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