[HTML][HTML] Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies

Y Wang, C Liu, C Zhang, Y Wang, Q Hong, S Xu… - Nature …, 2022 - nature.com
Abstract The SARS-CoV-2 Delta variant is currently the dominant circulating strain in the
world. Uncovering the structural basis of the enhanced transmission and altered immune …

Mutation-induced changes in the receptor-binding interface of the SARS-CoV-2 Delta variant B. 1.617. 2 and implications for immune evasion

P Baral, N Bhattarai, ML Hossen, V Stebliankin… - Biochemical and …, 2021 - Elsevier
Following the initial surges of the Alpha (B. 1.1. 7) and the Beta (B. 1.351) variants, a more
infectious Delta variant (B. 1.617. 2) is now surging, further deepening the health crises …

[HTML][HTML] Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

R Wang, Q Zhang, J Ge, W Ren, R Zhang, J Lan, B Ju… - Immunity, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to
emerge during the global pandemic and may facilitate escape from current antibody …

[HTML][HTML] Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants

JW Saville, D Mannar, X Zhu, SS Srivastava… - Nature …, 2022 - nature.com
Abstract The Delta and Kappa variants of SARS-CoV-2 co-emerged in India in late 2020,
with the Delta variant underlying the resurgence of COVID-19, even in countries with high …

In vitro data suggest that Indian delta variant B. 1.617 of SARS‐CoV‐2 escapes neutralization by both receptor affinity and immune evasion

G Augusto, MO Mohsen, S Zinkhan, X Liu, M Vogel… - Allergy, 2022 - Wiley Online Library
Background Emerged mutations can be attributed to increased transmissibility of the B.
1.617 and B. 1.36 Indian delta variants of SARS‐CoV‐2, most notably substitutions …

[HTML][HTML] Omicron: a heavily mutated SARS-CoV-2 variant exhibits stronger binding to ACE2 and potently escapes approved COVID-19 therapeutic antibodies

M Shah, HG Woo - Frontiers in immunology, 2022 - frontiersin.org
The new SARS-CoV-2 variant of concern “Omicron” was recently spotted in South Africa and
spread quickly around the world due to its enhanced transmissibility. The variant became …

[HTML][HTML] S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular …

F Ye, X Lin, Z Chen, F Yang, S Lin, J Yang… - … and Targeted Therapy, 2021 - nature.com
Abstract SARS-CoV-2 recognizes, via its spike receptor-binding domain (S-RBD), human
angiotensin-converting enzyme 2 (ACE2) to initiate infection. Ecto-domain protein of ACE2 …

[HTML][HTML] Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM

Y Wang, C Xu, Y Wang, Q Hong, C Zhang, Z Li… - Nature …, 2021 - nature.com
The emergence of SARS-CoV-2 Kappa and Beta variants with enhanced transmissibility
and resistance to neutralizing antibodies has created new challenges for the control of the …

[HTML][HTML] Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant

L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch… - Cell, 2020 - cell.com
Summary The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus
worldwide, reaching near fixation in a matter of months. Here we show that D614G was …

[HTML][HTML] Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level

R Zhu, D Canena, M Sikora, M Klausberger… - nature …, 2022 - nature.com
Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …