The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …

Cardiovascular disease is a major complication of diabetes mellitus, and improved
strategies for prevention and treatment are needed. Endothelial dysfunction contributes to …

Micro-and macrovascular complications are major causes of disability and death in patients
with diabetes mellitus. Functional impairment of endothelial activity precedes the …

Diabetes-associated vascular complications are collectively the major clinical problems
facing patients with diabetes and lead to the considerably higher mortality rate than that of …

Endothelial dysfunction plays a key role in the initiation of cellular events evolving into the
development of vascular complications in diabetes and hypertension. Diminished …

The endothelium, although only a single layer of cells lining the vascular and lymphatic
systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 …

Endothelial dysfunction is universal in diabetes, being intimately involved with the
development of cardiovascular disease. The pathogenesis of endothelial dysfunction in …

Abstract Type 2 diabetes (T2D) markedly increases the risk of cardiovascular disease.
Endothelial dysfunction (ED), an early indicator of diabetic vascular disease, is common in …

Diabetes mellitus, a metabolic disorder characterised by high levels of blood glucose, is
associated with several vascular complications. Although insulin treatment, oral …

Although the etiology of vascular dysfunction in diabetes has been extensively investigated
in both humans as well as animal models of human diabetes, the relative importance of the …