[HTML][HTML] De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts
Y Xu, X Wang, C Zhang, X Zhou, X Xu, L Han… - Nature …, 2022 - nature.com
High-sugar diet causes health problems, many of which can be addressed with the use of
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …
[HTML][HTML] Microbial production of next-generation stevia sweeteners
K Olsson, S Carlsen, A Semmler, E Simón… - Microbial cell …, 2016 - Springer
Abstract Background The glucosyltransferase UGT76G1 from Stevia rebaudiana is a
chameleon enzyme in the targeted biosynthesis of the next-generation premium stevia …
chameleon enzyme in the targeted biosynthesis of the next-generation premium stevia …
[HTML][HTML] Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production
Resveratrol is a plant secondary metabolite with multiple health-beneficial properties.
Microbial production of resveratrol in model microorganisms requires extensive engineering …
Microbial production of resveratrol in model microorganisms requires extensive engineering …
[HTML][HTML] De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories
Isoflavonoids comprise a class of plant natural products with great nutraceutical,
pharmaceutical and agricultural significance. Their low abundance in nature and structural …
pharmaceutical and agricultural significance. Their low abundance in nature and structural …
Optimizing oleaginous yeast cell factories for flavonoids and hydroxylated flavonoids biosynthesis
Plants possess myriads of secondary metabolites with a broad spectrum of health-promoting
benefits. To date, plant extraction is still the primary route to produce high-value natural …
benefits. To date, plant extraction is still the primary route to produce high-value natural …
[HTML][HTML] Metabolic engineering Saccharomyces cerevisiae for de novo production of the sesquiterpenoid (+)-nootkatone
X Meng, H Liu, W Xu, W Zhang, Z Wang, W Liu - Microbial cell factories, 2020 - Springer
Abstract Background (+)-Nootkatone is a highly valued sesquiterpenoid compound,
exhibiting a typical grapefruit aroma and various desired biological activities for use as …
exhibiting a typical grapefruit aroma and various desired biological activities for use as …
[HTML][HTML] De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae
Resveratrol is a natural antioxidant compound, used as food supplement and cosmetic
ingredient. Microbial production of resveratrol has until now been achieved by …
ingredient. Microbial production of resveratrol has until now been achieved by …
An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids
P Arendt, K Miettinen, J Pollier, R De Rycke… - Metabolic …, 2017 - Elsevier
Saponins are a structurally diverse family of triterpenes that are widely found as main
constituents in many traditional plant-based medicines and often have bioactivities of …
constituents in many traditional plant-based medicines and often have bioactivities of …
Combinatorial metabolic engineering enables the efficient production of ursolic acid and oleanolic acid in Saccharomyces cerevisiae
K Jin, X Shi, J Liu, W Yu, Y Liu, J Li, G Du, X Lv… - Bioresource …, 2023 - Elsevier
Ursolic acid (UA) and oleanolic acid (OA) have been demonstrated to have promising
therapeutic potential as anticancer and bacteriostasis agents. Herein, via the heterologous …
therapeutic potential as anticancer and bacteriostasis agents. Herein, via the heterologous …
Engineering yeast metabolism for production of terpenoids for use as perfume ingredients, pharmaceuticals and biofuels
Terpenoids represent a large class of natural products with significant commercial
applications. These chemicals are currently mainly obtained through extraction from plants …
applications. These chemicals are currently mainly obtained through extraction from plants …