[HTML][HTML] De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts

Y Xu, X Wang, C Zhang, X Zhou, X Xu, L Han… - Nature …, 2022 - nature.com
High-sugar diet causes health problems, many of which can be addressed with the use of
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …

[HTML][HTML] Microbial production of next-generation stevia sweeteners

K Olsson, S Carlsen, A Semmler, E Simón… - Microbial cell …, 2016 - Springer
Abstract Background The glucosyltransferase UGT76G1 from Stevia rebaudiana is a
chameleon enzyme in the targeted biosynthesis of the next-generation premium stevia …

[HTML][HTML] Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production

J Sáez-Sáez, G Wang, ER Marella, S Sudarsan… - Metabolic …, 2020 - Elsevier
Resveratrol is a plant secondary metabolite with multiple health-beneficial properties.
Microbial production of resveratrol in model microorganisms requires extensive engineering …

[HTML][HTML] De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

Q Liu, Y Liu, G Li, O Savolainen, Y Chen… - Nature …, 2021 - nature.com
Isoflavonoids comprise a class of plant natural products with great nutraceutical,
pharmaceutical and agricultural significance. Their low abundance in nature and structural …

Optimizing oleaginous yeast cell factories for flavonoids and hydroxylated flavonoids biosynthesis

Y Lv, M Marsafari, M Koffas, J Zhou, P Xu - ACS Synthetic Biology, 2019 - ACS Publications
Plants possess myriads of secondary metabolites with a broad spectrum of health-promoting
benefits. To date, plant extraction is still the primary route to produce high-value natural …

[HTML][HTML] Metabolic engineering Saccharomyces cerevisiae for de novo production of the sesquiterpenoid (+)-nootkatone

X Meng, H Liu, W Xu, W Zhang, Z Wang, W Liu - Microbial cell factories, 2020 - Springer
Abstract Background (+)-Nootkatone is a highly valued sesquiterpenoid compound,
exhibiting a typical grapefruit aroma and various desired biological activities for use as …

[HTML][HTML] De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

M Li, KR Kildegaard, Y Chen, A Rodriguez… - Metabolic …, 2015 - Elsevier
Resveratrol is a natural antioxidant compound, used as food supplement and cosmetic
ingredient. Microbial production of resveratrol has until now been achieved by …

An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids

P Arendt, K Miettinen, J Pollier, R De Rycke… - Metabolic …, 2017 - Elsevier
Saponins are a structurally diverse family of triterpenes that are widely found as main
constituents in many traditional plant-based medicines and often have bioactivities of …

Combinatorial metabolic engineering enables the efficient production of ursolic acid and oleanolic acid in Saccharomyces cerevisiae

K Jin, X Shi, J Liu, W Yu, Y Liu, J Li, G Du, X Lv… - Bioresource …, 2023 - Elsevier
Ursolic acid (UA) and oleanolic acid (OA) have been demonstrated to have promising
therapeutic potential as anticancer and bacteriostasis agents. Herein, via the heterologous …

Engineering yeast metabolism for production of terpenoids for use as perfume ingredients, pharmaceuticals and biofuels

Y Zhang, J Nielsen, Z Liu - FEMS Yeast Research, 2017 - academic.oup.com
Terpenoids represent a large class of natural products with significant commercial
applications. These chemicals are currently mainly obtained through extraction from plants …