PI3K/AKT/mTOR pathway in angiogenesis
J Karar, A Maity - Frontiers in molecular neuroscience, 2011 - frontiersin.org
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
pathway is activated in the majority of human cancers. This pathway is known to play a key …
pathway is activated in the majority of human cancers. This pathway is known to play a key …
PI3K/PTEN signaling in angiogenesis and tumorigenesis
BH Jiang, LZ Liu - Advances in cancer research, 2009 - Elsevier
Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …
PI3K/PTEN signaling in tumorigenesis and angiogenesis
BH Jiang, LZ Liu - Biochimica et biophysica acta (bba)-proteins and …, 2008 - Elsevier
The phosphatidyl inositol 3-kinase (PI3K) can be activated by a variety of extracellular
signals and involved in a number of cellular processes including cell proliferation, survival …
signals and involved in a number of cellular processes including cell proliferation, survival …
Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis
S Brader, SA Eccles - Tumori Journal, 2004 - journals.sagepub.com
Aims and background The PI3 kinase signalling pathway is now accepted as being at least
as important as the ras-MAP kinase pathway in cell survival and proliferation, and hence its …
as important as the ras-MAP kinase pathway in cell survival and proliferation, and hence its …
Class 1A PI3K regulates vessel integrity during development and tumorigenesis
TL Yuan, HS Choi, A Matsui, C Benes… - Proceedings of the …, 2008 - National Acad Sciences
PI3K is important in the regulation of growth, proliferation, and survival of tumor cells. We
show that class 1A PI3K is also critical in the tumor microenvironment by regulating the …
show that class 1A PI3K is also critical in the tumor microenvironment by regulating the …
The relation between PI3K/AKT signalling pathway and cancer
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
Role of receptor tyrosine kinases mediated signal transduction pathways in tumor growth and angiogenesis—New insight and futuristic vision
In the past two decades, significant progress has been made in the past two decades
towards the understanding of the basic mechanisms underlying cancer growth and …
towards the understanding of the basic mechanisms underlying cancer growth and …
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
MY Lee, AK Luciano, E Ackah… - Proceedings of the …, 2014 - National Acad Sciences
The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including
cell growth, migration, survival, and vascular tone. However, existing literature supports the …
cell growth, migration, survival, and vascular tone. However, existing literature supports the …
Targeting PI3 kinase/AKT/mTOR signaling in cancer
K Sheppard, KM Kinross, B Solomon… - Critical Reviews™ in …, 2012 - dl.begellhouse.com
The phosphatidylinositol 3 kinase (PI3K) pathway is one of the major pathways modulating
cell growth, proliferation, metabolism, survival, and angiogenesis. Hyperactivation of this …
cell growth, proliferation, metabolism, survival, and angiogenesis. Hyperactivation of this …
[HTML][HTML] PI3K and AKT: unfaithful partners in cancer
S Faes, O Dormond - International journal of molecular sciences, 2015 - mdpi.com
The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular
processes. An overactivation of the pathway is frequently present in human malignancies …
processes. An overactivation of the pathway is frequently present in human malignancies …