The lungs are essential for gas exchange and serve as the gateways of our body to the
external environment. They are easily accessible for drugs from both sides, the airways and …

The lungs as the gateways of our body to the external environment are essential for gas
exchange. They are also exposed to toxicants from two sides, the airways and the …

Chronic obstructive pulmonary disease (COPD) and asthma are both common respiratory
diseases that are associated with airflow reduction/obstruction and pulmonary inflammation …

Members of the transient receptor potential (TRP) superfamily are broadly expressed in our
body and contribute to multiple cellular functions. Most interestingly, the fourth member of …

Our respiratory system is exposed to toxicants and pathogens from both sides: the airways
and the vasculature. While tracheal, bronchial and alveolar epithelial cells form a natural …

Introduction: Chronic respiratory diseases, such as asthma and chronic obstructive
pulmonary disease, affect millions of patients worldwide. New therapeutic approaches to …

Over the last few decades, there has been an explosion of scientific publications reporting
the many and varied roles of transient receptor potential (TRP) ion channels in physiological …

Transient receptor potential (TRP) channels are emerging as important players and drug
targets in respiratory disease. Amongst the vanilloid-type TRP channels (which includes the …

Novel effective therapeutic agents are actively sought for the treatment of a broad spectrum
of respiratory diseases which collectively significantly impact on mortality, morbidity and …

There is rapidly growing evidence indicating multiple and important roles of Ca2+-
permeable cation TRP channels in the airways, both under normal and disease conditions …