Proteasome inhibitors have effective anti-tumor activity in cell culture and can induce
apoptosis by interfering with the degradation of cell cycle proteins. 20S Proteasome is …

Proteasomal system plays an important role in maintaining cell homeostatis. Overexpression
of proteasomes leads to several major diseases, such as cancer and autoimmune disorder …

The abnormal ubiquitin-proteasome is found as an important target in various human
diseases, especially in cancer, and recently it has received prevalent attention as a …

Proteasome emerged as an important target in recent pharmacological research due to its
pivotal role in degrading proteins in the cytoplasm and nucleus of eukaryotic cells …

Cancer is a complex multifactorial disease whose pathophysiology involves multiple
metabolic pathways, including the ubiquitin–proteasome system, for which several …

Many studies and observations suggest proteasomes are multimeric proteolytic enzyme
complexes that play a central role in degradation of protein in animal cells. Several basic …

Aim: The purpose of this paper is to use different structures and ligand-based drug design
methods properly to provide theoretical guidance for the design of novel non-covalent …

Proteasome inhibitors have been proved to be effective in regulated intracellular proteolysis.
Three Dimensional Quantitative Structure Activity Relationships and Molecular docking …

The ubiquitin–proteasome pathway plays a pivotal role in the regulation of cellular protein
processing and degradation. Proteasome inhibitors (PIs) have enormous potential to treat …

Multiple myeloma is a most uncommon cancer of plasma cells found to be prevalent in
people aged over 65. It is caused by the degradation of I-кB an inhibitor of NF-кB cell by 26S …