Protein noise measurements are increasingly used to elucidate biophysical parameters.
Unfortunately noise analyses are often at odds with directly measured parameters. Here we …

The ability of cells to accurately control gene expression levels in response to extracellular
cues is limited by the inherently stochastic nature of transcriptional regulation. A change in …

In order to grow and replicate, living cells must express a diverse array of proteins, but the
process by which proteins are made includes a great deal of inherent randomness …

The intrinsic stochasticity of gene expression leads to cell-to-cell variations, noise, in protein
abundance. Several processes, including transcription, translation, and degradation of …

Protein levels differ considerably between otherwise identical cells, and these differences
significantly affect biological function and phenotype. Previous work implicated various …

The relative contribution of promoter architecture and the associated chromatin environment
in regulating gene expression noise has remained elusive. In their recent work, Arkin …

For just over a decade, stochastic gene expression has been the focus of many
experimental and theoretical studies. It is now widely accepted that noise in gene …

Cell-to-cell variation in gene expression, or noise, is a general phenomenon observed
within cell populations. Transcription is known to be the key stage of gene expression where …

Although it is well appreciated that gene expression is inherently noisy and that
transcriptional noise is encoded in a promoter's sequence, little is known about the extent to …

Gene expression is a stochastic process. Despite the increase of protein numbers in
growing cells, the protein concentrations are often found to be confined within small ranges …