The liver is situated at the interface of the gut and circulation where it acts as a filter for blood-
borne and gut-derived microbes and biological molecules, promoting tolerance of non …

Macrophages are key regulators of inflammation and repair, but their heterogeneity and
multiple roles in the liver are not fully understood. We aimed herein to map the intrahepatic …

The liver is an essential immunological organ due to its gatekeeper position to bypassing
antigens from the intestinal blood flow and microbial products from the intestinal …

Macrophages are a heterogeneous population of innate immune cells and key cellular
components of the liver. Hepatic macrophages consist of embryologically-derived resident …

Kupffer cells are the primary liver resident immune cell responsible for the liver firewall
function, including clearance of bacterial infection from the circulation, as they are …

The liver has a remarkable capacity to regenerate after injury; yet, the role of macrophages
(MF) in this process remains controversial mainly due to difficulties in distinguishing …

Ample evidence suggests that hepatic macrophages play key roles in the injury and repair
mechanisms during liver disease progression. There are two major populations of hepatic …

Different etiologies such as drug toxicity, acute viral hepatitis B, or acetaminophen poisoning
can cause acute liver injury or even acute liver failure (ALF). Excessive cell death of …

Multiple potentially harmful stimuli challenge the liver, the chief metabolic and detoxifying
organ of the human body. Due to its central anatomical location, continuous blood flow from …

Macrophages hold a critical position in the pathogenesis of liver injury and repair, in which
their infiltrations is regarded as a main feature for both acute and chronic liver diseases. It is …