[HTML][HTML] Advances in molecular characterization of pediatric acute megakaryoblastic leukemia not associated with Down syndrome; impact on therapy development
J Li, ML Kalev‐Zylinska - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia
(AML) in which leukemic blasts have megakaryocytic features. AMKL makes up 4-15% of …
(AML) in which leukemic blasts have megakaryocytic features. AMKL makes up 4-15% of …
Clinical impact of genomic characterization of 15 patients with acute megakaryoblastic leukemia–related malignancies
E Lalonde, S Rentas, G Wertheim… - Molecular …, 2021 - molecularcasestudies.cshlp.org
Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia but is
approximately 500 times more likely to develop in children with Down syndrome (DS) …
approximately 500 times more likely to develop in children with Down syndrome (DS) …
Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes
JDE De Rooij, C Branstetter, J Ma, Y Li, MP Walsh… - Nature …, 2017 - nature.com
Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia (AML) in
which cells morphologically resemble abnormal megakaryoblasts. While rare in adults …
which cells morphologically resemble abnormal megakaryoblasts. While rare in adults …
The changing scenario of non-Down syndrome acute megakaryoblastic leukemia in children
R Masetti, V Guidi, L Ronchini, NS Bertuccio… - Critical reviews in …, 2019 - Elsevier
Pediatric non-Down-syndrome acute megakaryoblastic leukemia (non-DS-AMKL) is a
heterogeneous subtype of leukemia that has historically been associated with poor …
heterogeneous subtype of leukemia that has historically been associated with poor …
Molecular features, prognosis, and novel treatment options for pediatric acute megakaryoblastic leukemia
F De Marchi, M Araki, N Komatsu - Expert Review of Hematology, 2019 - Taylor & Francis
ABSTRACT Introduction: Acute megakaryoblastic leukemia (AMegL) is a rare hematological
neoplasm most often diagnosed in children and is commonly associated with Down's …
neoplasm most often diagnosed in children and is commonly associated with Down's …
Pediatric acute megakaryoblastic leukemia: multitasking fusion proteins and oncogenic cooperations
Pediatric leukemia presents specific clinical and genetic features from adult leukemia but the
underpinning mechanisms of transformation are still unclear. Acute megakaryoblastic …
underpinning mechanisms of transformation are still unclear. Acute megakaryoblastic …
Acute megakaryocytic leukemia
M McNulty, JD Crispino - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
Acute megakaryoblastic leukemia (AMKL) is a rare malignancy affecting megakaryocytes,
platelet-producing cells that reside in the bone marrow. Children with Down syndrome (DS) …
platelet-producing cells that reside in the bone marrow. Children with Down syndrome (DS) …
The biology of pediatric acute megakaryoblastic leukemia
TA Gruber, JR Downing - Blood, The Journal of the American …, 2015 - ashpublications.org
Acute megakaryoblastic leukemia (AMKL) comprises between 4% and 15% of newly
diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down …
diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down …
[HTML][HTML] A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy
Background Acute megakaryocytic leukemia (AMkL) in Down syndrome (DS) children is
uniformly associated with somatic GATA1 mutations, which result in the synthesis of a …
uniformly associated with somatic GATA1 mutations, which result in the synthesis of a …
Outcome and prognostic features in pediatric acute megakaryoblastic leukemia without down syndrome: A retrospective study in China
Y Wang, A Lu, Y Jia, Y Zuo, L Zhang - Clinical Lymphoma Myeloma and …, 2021 - Elsevier
Background Acute megakaryoblastic leukemia (AMKL) is a biologically heterogeneous
subtype of acute myeloid leukemia that originates from megakaryocytes. Patients with AMKL …
subtype of acute myeloid leukemia that originates from megakaryocytes. Patients with AMKL …