Background In the absence of curative treatment, such as stem cell transplant, regular
transfusions remain the mainstay of therapy for individuals with thalassemia major, a …

Chronic transfusion, used to manage clinically significant forms of thalassemia, carries
complication risks including iron overload, alloimmunization, and allergic or hemolytic …

BACKGROUND The severe forms of thalassemia are the most common inherited anemias
managed with regular blood transfusion therapy. Transfusion policies and complications are …

The introduction of regular red cell transfusions 60 years ago transformed β-thalassemia
major from a fatal childhood illness into a chronic disorder. Further advances in the …

Notwithstanding the high safety level of the currently available blood for transfusion and the
decreasing frequency of transfusion-related complications, administration of labile blood …

BLOOD TRANSFUSION - Guidelines for the Management of Transfusion Dependent
Thalassaemia (TDT) - NCBI Bookshelf US flag An official website of the United States government …

Enhancements in the global care of thalassemia, resulting from the combination of an
appropriate transfusion approach and iron chelation therapy, have produced a significant …

Guidelines for minimizing risks from alloimmunization, other transfusion reactions, and
infection risks are presented based on the Thalassemia International Federation (TIF) …

Chronic transfusion therapy has played a central role in extending life expectancy for
patients with hemoglobinopathies such as thalassemia. However, this life-saving therapy is …

Transfusion combined with chelation therapy for severe β thalassemia syndromes
(transfusion-dependent thalassemia [TDT]) has been successful in extending life …