CD8+ T cells are critical for elimination of cancer cells. Factors within the tumor
microenvironment (TME) can drive these cells to a hypofunctional state known as …

The ability of CD8+ T lymphocytes to eliminate tumors is limited by their ability to engender
an immunosuppressive microenvironment. Here we describe a subset of tumor-infiltrating …

Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other
suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction …

T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the
mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) …

Tumor-specific CD8+ T cells are exposed to persistent antigenic stimulation which induces a
dysfunctional state called “exhaustion.” Though functioning to limit damage caused by …

Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …

Depleting regulatory T cells (Treg cells) to counteract immunosuppressive features of the
tumor microenvironment (TME) is an attractive strategy for cancer treatment; however …

In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …

Abstract Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector
function, high co-expression of inhibitory receptors and extensive transcriptional changes …

CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …