The intercalated discs that connect cardiomyocytes control cell-to-cell adhesion and
communication. Several macromolecular structures (desmosomes, fascia adherens …

This review summarizes data in support of the notion that the cardiac intercalated disc is the
host of a protein interacting network, called “the connexome”, where molecules classically …

For the last 10 years, applying new sequencing technologies to thousands of whole exomes
has revealed the high variability of the human genome. Extreme caution should thus be …

Arrhythmogenic cardiomyopathy (ACM) and Brugada syndrome (BrS) are inherited diseases
characterized by an increased risk for arrhythmias and sudden cardiac death. Possible …

2 Corrado et al ARVC vs Brugada Syndrome reexcitation) leading to rapid polymorphic VT,
which can degenerate into VF (repolarization theory) 7, 8 (Figure 2). On the contrary …

Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to
dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to …

The main inherited cardiac arrhythmias are long QT syndrome, short QT syndrome,
catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome. These rare …

Brugada syndrome (BrS) is one of the commonest inherited primary arrhythmia syndromes
typically presenting with arrhythmic syncope or sudden cardiac death (SCD) due to …

Brugada syndrome (BrS) is a relatively rare arrhythmia disorder that can lead to sudden
cardiac death (SCD) due to ventricular tachycardia/fibrillation (VT/VF), predominantly in …

Abstract Aims The Brugada syndrome (BrS) is an inherited cardiac disorder predisposing to
ventricular arrhythmias. Despite considerable efforts, its genetic basis and cellular …