High-grade serous ovarian cancer (HG-SOC)—often referred to as a “silent killer”—is the
most lethal gynecological malignancy. The fallopian tube (murine oviduct) and ovarian …

Transplantable murine models of ovarian high grade serous carcinoma (HGSC) remain an
important research tool. We previously showed that ID8, a widely-used syngeneic model of …

There is a need for transplantable murine models of ovarian high-grade serous carcinoma
(HGSC) with regard to mutations in the human disease to assist investigations of the …

The paucity of genetically informed, immunocompetent tumor models impedes evaluation of
conventional, targeted, and immune therapies. By engineering mouse fallopian tube …

The cell-of-origin of high grade serous ovarian carcinoma (HGSOC) remains controversial,
with fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) both considered …

High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer
and has a poor outcome. It has been proposed that fallopian tube cancers may be …

High‐grade serous ovarian cancer (HGSOC) likely originates from the fallopian tube (FT)
epithelium. Here, we established 15 organoid lines from HGSOC primary tumor deposits that …

Epithelial ovarian cancers (EOCs) are sensitive to chemotherapy but will ultimately relapse
and develop drug resistance. The origin of EOC recurrence has been elusive due to intra …

Recent developments in the study of epithelial ovarian cancer have called into question the
traditional views regarding the site of tumor initiation. Histopathologic studies and genomic …

The broad research use of organoids from high-grade serous ovarian cancer (HGSC) has
been hampered by low culture success rates and limited availability of fresh tumor material …