Association of resveratrol with the suppression of TNF-α/NF-kB/iNOS/HIF-1α axis-mediated fibrosis and systemic hypertension in thioacetamide-induced liver injury

HA Ebrahim, SS Kamar, MA Haidara, NSA Latif… - Naunyn-Schmiedeberg's …, 2022 - Springer
Chronic liver injury can lead to hepatic failure and the only available method of treatment
would be liver transplantation. The link between inflammation (TNF-α), nuclear factor-kappa …

[HTML][HTML] Resveratrol prevents liver fibrosis via two possible pathways: Modulation of alpha fetoprotein transcriptional levels and normalization of protein kinase C …

AF Hessin, RR Hegazy, AA Hassan… - Indian journal of …, 2017 - journals.lww.com
OBJECTIVE: Liver fibrosis is a global health problem that causes approximately 1.4 million
deaths per year. It is associated with inflammation, oxidative stress, necrosis and ends with …

[HTML][HTML] Resveratrol attenuates the progress of liver fibrosis via the Akt/nuclear factor-κB pathways

H Zhang, Q Sun, T Xu, L Hong… - Molecular …, 2016 - spandidos-publications.com
Liver fibrosis is a wound-healing response to chronic liver injury that results in the
accumulation of extracellular matrix proteins. It eventually leads to cirrhosis of the liver and …

[HTML][HTML] Resveratrol alleviates hepatic fibrosis in associated with decreased endoplasmic reticulum stress-mediated apoptosis and inflammation

Z Ma, L Sheng, J Li, J Qian, G Wu, Z Wang, Y Zhang - Inflammation, 2022 - Springer
Hepatic fibrosis (HF) is the typical response to chronic liver disease and is characterized by
deposition of abundant extracellular matrix. The aim of the present study was to investigate …

[HTML][HTML] Lycorine ameliorates thioacetamide-induced hepatic fibrosis in rats: emphasis on antioxidant, anti-inflammatory, and STAT3 inhibition effects

HM Alkreathy, A Esmat - Pharmaceuticals, 2022 - mdpi.com
Liver fibrosis is a foremost medical concern worldwide. In Saudi Arabia, numerous risk
factors contribute to its high rates. Lycorine—a natural alkaloid—has antioxidant, anti …

Carvacrol hinders the progression of hepatic fibrosis via targeting autotaxin and thioredoxin in thioacetamide-induced liver fibrosis in rat

ZA El-Gendy, A Ramadan… - Human & …, 2021 - journals.sagepub.com
Fibrosis is a common outcome of nearly all chronic diseases of liver that results in changes
of its functions which requires medical attention. The current research aims to investigate the …

Resveratrol suppresses cholestasis‐induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1–Smad3–miR21 axis and profibrogenic and hepatic …

AM ShamsEldeen, B Al‐Ani… - Clinical and …, 2021 - Wiley Online Library
Cholestasis caused by slowing or blockage of bile flow is a serious liver disease that can
lead to liver fibrosis and cirrhosis. The link between transforming growth factor beta 1 …

Apigenin role against thioacetamide-triggered liver fibrosis: deciphering the PPARγ/TGF-β1/NF-κB and the HIF/FAK/AKT pathways

RF Abdel-Rahman, HM Fayed… - Journal of …, 2023 - herbmedpharmacol.com
Introduction: Liver tissue malfunction is a severe worldwide health concern that arises from
various chronic liver conditions. The goal of this investigation was to look into the antifibrotic …

Metformin inhibits mTOR–HIF‐1α axis and profibrogenic and inflammatory biomarkers in thioacetamide‐induced hepatic tissue alterations

F Al‐Hashem, S Al‐Humayed, SN Amin… - Journal of cellular …, 2019 - Wiley Online Library
The potential inhibitory effect of the antidiabetic and anti‐inflammatory drug, metformin on
thioacetamide (TAA)‐induced hepatotoxicity associated with the inhibition of mammalian …

The anti-inflammatory and anti-fibrotic effects of tadalafil in thioacetamide-induced liver fibrosis in rats

HM Mansour, AAA Salama… - Canadian Journal of …, 2018 - cdnsciencepub.com
Liver fibrosis is a health concern that leads to organ failure mediated via production of
inflammatory cytokines and fibrotic biomarkers. This study aimed to explore the protective …