Background Antibody-mediated complement fixation has previously been associated with
protection against malaria in naturally acquired immunity. However, the process of early-life …

Abstract Background Antibodies targeting Plasmodium falciparum sporozoites play a key
role in human immunity to malaria. However, antibody mechanisms that neutralize …

Abstract Background Immunoglobulin G (IgG) antibodies are thought to play important roles
in the protection against Plasmodium falciparum (P. falciparum) malaria. A longitudinal …

Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication
in naturally-acquired and vaccine-induced immunity; however, specific targets of these …

Background Plasmodium falciparum malaria is a leading cause of child mortality in Nigeria.
Neonates are born with maternal antibodies from placental transfer which may protect …

Background Antibodies targeting malaria blood-stage antigens are important targets of
naturally acquired immunity, and may act as valuable biomarkers of malaria exposure …

Background Substantial evidence indicates that cytophilic IgG responses to Plasmodium
falciparum merozoite antigens play a role in protection from malaria. The specific targets …

Background In holoendemic areas, children suffer the most from Plasmodium falciparum
malaria, yet newborns and young infants express a relative resistance to both infection and …

Background The specific targets of functional antibodies against Plasmodium falciparum
merozoites remain largely unexplored and, more importantly, their relevance to naturally …

Identifying the mechanism of naturally acquired immunity against Plasmodium falciparum
malaria could contribute to the design of effective malaria vaccines. Using a recently …