[HTML][HTML] Effect of glutamate infusion on NT-proBNP after coronary artery bypass grafting in high-risk patients (GLUTAMICS II): A randomized controlled trial

J Holm, G Ferrari, A Holmgren, F Vanky, Ö Friberg… - PLoS …, 2022 - journals.plos.org
Background Animal and human data suggest that glutamate can enhance recovery of
myocardial metabolism and function after ischemia. N-terminal pro-brain natriuretic peptide …

[HTML][HTML] The impact of glutamate infusion on postoperative NT-proBNP in patients undergoing coronary artery bypass surgery: a randomized study

H Jiang, J Holm, M Vidlund, F Vanky, Ö Friberg… - Journal of Translational …, 2020 - Springer
Background Glutamate, a key intermediate in myocardial metabolism, may enhance
myocardial recovery after ischemia and possibly reduce the incidence and severity of …

[HTML][HTML] Glutamate Infusion Reduces Myocardial Dysfunction after Coronary Artery Bypass Grafting According to NT-proBNP: Summary of 2 Randomized Controlled …

J Holm, F Vanky, R Svedjeholm - The American Journal of Clinical Nutrition, 2023 - Elsevier
Background Glutamate is reported to enhance the recovery of oxidative metabolism and
contractile function of the heart after ischemia. The effect appears to be blunted in diabetic …

Association of Glutamate Infusion With Risk of Acute Kidney Injury After Coronary Artery Bypass Surgery: A Pooled Analysis of 2 Randomized Clinical Trials

J Holm, F Vanky, R Svedjeholm - JAMA Network Open, 2024 - jamanetwork.com
Importance Acute kidney injury (AKI) after cardiac surgery is associated with increased
morbidity and mortality, and measures to prevent AKI have had limited success. Glutamate …

[HTML][HTML] GLUTAMICS—a randomized clinical trial on glutamate infusion in 861 patients undergoing surgery for acute coronary syndrome

M Vidlund, E Håkanson, Ö Friberg… - The Journal of thoracic …, 2012 - Elsevier
OBJECTIVE: Glutamate has been claimed to protect the heart from ischemia and to facilitate
metabolic and hemodynamic recovery after ischemia. The GLUTAmate for Metabolic …

[HTML][HTML] Post hoc analysis of the glutamics–trial: intravenous glutamate infusion and use of inotropic drugs after cabg

M Vidlund, B Tajik, E Håkanson, Ö Friberg, J Holm… - BMC …, 2015 - Springer
Background Intravenous glutamate reduced the risk of developing severe circulatory failure
after isolated coronary artery bypass graft surgery (CABG) for acute coronary syndrome …

[HTML][HTML] Glutamine is cardioprotective in patients with ischemic heart disease following cardiopulmonary bypass

VV Lomivorotov, SM Efremov, VA Shmirev… - The heart surgery …, 2011 - journal.hsforum.com
Background: The aim of the present study was to investigate the cardioprotective effects of
the perioperative use of N (2)-L-alanyl-L-glutamine (GLN) in patients with ischemic heart …

Does glutamine promote benefits for patients with diabetes mellitus scheduled for cardiac surgery?

VV Lomivorotov, SM Efremov, VA Shmirev… - Heart, Lung and …, 2013 - Elsevier
BACKGROUND: We hypothesised, that perioperative use of N (2)-l-alanyl-l-glutamine
confers cardioprotection and improves insulin resistance in diabetic patients with coronary …

The supportive value of pre-bypass L-glutamate loading in patients undergoing coronary artery bypass grafting

G Bitzikas, C Papakonstantinou… - Journal of …, 2005 - search.proquest.com
AIM: Experimental studies have demonstrated that an exogenous supply of glutamate
improves mechanical function and recovery of ischemic myocardium. The aim of the present …

Change in plasma glutamate concentration during cardiac surgery is a poor predictor of cognitive outcome

JD Reynolds, DW Amory, HP Grocott, WD White… - Journal of cardiothoracic …, 2002 - Elsevier
Objective: To develop a simple and reliable method for quantitating plasma glutamate
concentration and apply this method to monitor systemic glutamate levels during coronary …