Background Cachexia involves unintentional body weight loss including diminished muscle
and adipose tissue mass and is associated with an underlying disease. Systemic …

A devastating aspect of cancer cachexia is severe loss of muscle and fat mass. Though
cachexia occurs in both sexes, it is not well-defined in the female. The Apc Min/+ mouse is …

The Apc Min/+ mouse has a mutation in the Apc tumor suppressor gene and develops
intestinal polyps, beginning at 4 wk of age. This mouse develops cachexia by 6 mo …

Abstract Interleukin-6 (IL-6) is necessary for cachexia in Apc Min/+ mice, but the
mechanisms inducing this myofiber wasting have not been established. The purpose of this …

Background Muscle protein turnover regulation during cancer cachexia is being rapidly
defined, and skeletal muscle mitochondria function appears coupled to processes regulating …

Criteria for diagnosing cachexia in adults include unintentional loss in body weight,
decreased strength, fatigue, anorexia, and low muscle mass. Cachexia is also associated …

ABSTRACT MACPHERSON, REK, JS HUBER, S. FRENDO-CUMBO, JA SIMPSON, and DC
WRIGHT. Adipose Tissue Insulin Action and IL-6 Signaling after Exercise in Obese Mice …

Cancer cachexia is a complicated disorder of extreme, progressive skeletal muscle wasting.
It is directed by metabolic alterations and systemic inflammation dysregulation. Numerous …

Purpose To evaluate the effects of intensity of exercise on insulin resistance and the
expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats …

Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated
that IL6 activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating …