Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …

Simple Summary Nuclear protein 1 (NUPR1) is activated in cellular stress and is expressed
at high levels in cancer cells. Much evidence has been gathered supporting its critical role in …

Ferroptosis is an iron-dependent cell death characterized by the accumulation of
hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces …

Ferroptosis is a non-apoptotic mode of regulated cell death that is iron and lipid peroxidation
dependent. As new mechanistic insight into ferroptotic effectors and how they are regulated …

Ferroptosis is a regulated form of necrotic cell death caused by iron-dependent
accumulation of oxidized phospholipids in cellular membranes, culminating in plasma …

Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various
human diseases, including ischemic organ damage and cancer. Here, we report the crucial …

Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …

Ferroptosis is a recently recognized form of regulated cell death caused by an iron‐
dependent accumulation of lipid reactive oxygen species. However, the molecular …

Ferroptosis is an iron‐dependent form of non‐apoptotic cell death implicated in liver, brain,
kidney, and heart pathology. How ferroptosis is regulated remains poorly understood. Here …

The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process
of ferroptosis. How glutathione abundance is regulated in the cell and how this regulation …