The detailed metabolic map for camptothecin (CPT) biosynthesis in Camptotheca acuminata
has been proposed according to our combined omics results. However, the CYP450 …

Treatments with abiotic elicitors can efficiently induce the accumulation of specialized
metabolites in plants. We used a combined omics approach to analyze the elicitation effects …

Camptothecin is one of the most commonly used anticancer drugs worldwide, yet the
downstream biosynthetic route from strictosidine to camptothecin has remained unclear for …

Background Camptotheca acuminata is a Nyssaceae plant, often called the" happy tree",
which is indigenous in Southern China. C. acuminata produces the terpenoid indole …

Leaves, flowers, fruits and stems (44 sample groups) were collected from mature
Camptotheca acuminate during 2017.3–2018.3 and classified by ultra-high performance …

Dozens of triterpenes have been isolated from Camptotheca acuminata, however, triterpene
metabolism in this plant remains poorly understood. The common C28 carboxy located in …

Background The anticancer drug camptothecin (CPT), first isolated from Camptotheca
acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila …

Cytochrome P450 monooxygenases (CYP450s) and their auxiliary cytochrome P450
reductases (CPRs) are important and commonly involved in the biosynthesis of …

Camptothecin (CPT) is an antitumor alkaloid first isolated from Chinese tree Camptotheca
acuminata Decaisne (Nyssaceae). Several attempts have been made to improve CPT …

Camptotheca acuminata produces camptothecin (CPT), a monoterpene indole alkaloid
(MIA) that is widely used in the treatment of lung, colorectal, cervical, and ovarian cancers …