Endogenous tryptophan (Trp) metabolites have an important role in mammalian gut immune
homeostasis, yet the potential contribution of Trp metabolites from resident microbiota has …

The gut microbiota influences the health of the host, especially with regard to gut immune
homeostasis and the intestinal immune response. In addition to serving as a nutrient …

The trillions of commensal microorganisms comprising the gut microbiota have received
growing attention owing to their impact on host physiology. Recent advances in our …

Increasing evidence suggests a significant role for microbiota dependent metabolites and co-
metabolites, acting as aryl hydrocarbon receptor (AHR) ligands, to facilitate bidirectional …

Background Dysregulation of gut microbiota-associated tryptophan metabolism has been
observed in patients with multiple sclerosis. However, defining direct mechanistic links …

Tryptophan (Trp) is an essential amino acid primarily derived from the diet for use by the
host for protein synthesis. The intestinal tract is lined with cells, both host and microbial, that …

Commensal microbiota-dependent tryptophan catabolism within the gastrointestinal tract is
known to exert profound effects upon host physiology, including the maintenance of …

The gut microbiota is a crucial actor in human physiology. Many of these effects are
mediated by metabolites that are either produced by the microbes or derived from the …

Tryptophan (Trp) is not only a nutrient enhancer but also has systemic effects. Trp
metabolites signaling through the well-known aryl hydrocarbon receptor (AhR) constitute the …

Metazoans predominantly co-exist with symbiotic microorganisms called the microbiota.
Metagenomic surveys of the microbiota reveal a diverse ecosystem of microbes particularly …