In vitro evaluation of the effects of potential GSK-3β inhibitors terbutaline and orciprenaline
E Uzunhisarcıklı - Trakya University Journal of Natural Sciences, 2024 - dergipark.org.tr
Lung cancer is a type of cancer that is mostly diagnosed at an advanced stage and has a
short survival time despite standard chemotherapy and targeted therapies. Terbutaline and …
short survival time despite standard chemotherapy and targeted therapies. Terbutaline and …
GSK3β overexpression indicates poor prognosis and its inhibition reduces cell proliferation and survival of non-small cell lung cancer cells
J Zeng, D Liu, Z Qiu, Y Huang, B Chen, L Wang, H Xu… - PloS one, 2014 - journals.plos.org
Background Glycogen synthase kinase 3 beta (GSK3β) is centrally involved in diverse
cellular processes, including proliferation and apoptosis. This study aimed to investigate the …
cellular processes, including proliferation and apoptosis. This study aimed to investigate the …
Detection of active fraction of glycogen synthase kinase 3β in cancer cells by nonradioisotopic in vitro kinase assay
W Mai, K Miyashita, A Shakoori, B Zhang, ZW Yu… - Oncology, 2007 - karger.com
Glycogen synthase kinase 3β (GSK3β) is a well-known marker and potential therapeutic
target in non-insulin-dependent diabetes mellitus and Alzheimer's disease. Our recent …
target in non-insulin-dependent diabetes mellitus and Alzheimer's disease. Our recent …
Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer
F Wu, J Chen, LM Fan, K Liu… - Experimental and …, 2017 - spandidos-publications.com
The aim of the present study was to investigate the effect of rutin treatment on the expression
of glycogen synthase kinase (GSK)-3β and tumor necrosis factor (TNF)‑α in A549 human …
of glycogen synthase kinase (GSK)-3β and tumor necrosis factor (TNF)‑α in A549 human …
Modulation of GSK-3βactivity in cancer treatment
L Tao, X Sheng, Y Liu, Z Wei… - Chinese …, 2014 - pesquisa.bvsalud.org
As the major member of serine/threonine protein ki-nases family, glycogen synthase kinase
3β (GSK-3β) has well characterized roles in the development of a variety of diseases …
3β (GSK-3β) has well characterized roles in the development of a variety of diseases …
Glycogen synthase kinase 3 as an anticancer drug target: novel experimental findings and trends in the design of inhibitors
DI Osolodkin, VA Palyulin… - Current pharmaceutical …, 2013 - ingentaconnect.com
Glycogen synthase kinase 3 (GSK-3) is a ubiquitous serine/threonine protein kinase
participating in numerous pathways. Very important among them are cancer-related …
participating in numerous pathways. Very important among them are cancer-related …
[HTML][HTML] Glycogen synthase kinase-3β inhibitors as a novel promising target in the treatment of cancer: medicinal chemistry perspective
D Karati, KK Shaoo, KR Mahadik, D Kumr - Results in Chemistry, 2022 - Elsevier
Glycogen synthase kinase-3 beta (GSK-3β) is a desired pharmacological target for cancer
treatment. Despite its role in the development of various cancers, any target directing GSK-3 …
treatment. Despite its role in the development of various cancers, any target directing GSK-3 …
[PDF][PDF] O9Flaherty L, Pardo OE, Dzien P, et al.(2014) Glycogen Synthase Kinase 3 Protein Kinase Activity Is Frequently Elevated in Human Non-Small Cell Lung …
EE Vincent, DJE Elder - PLoS One, 2014 - academia.edu
Background: Glycogen synthase kinase 3 (GSK3) is a central regulator of cellular
metabolism, development and growth. GSK3 activity was thought to oppose tumourigenesis …
metabolism, development and growth. GSK3 activity was thought to oppose tumourigenesis …
Xanthone glucoside 2-β-D-glucopyranosyl-1, 3, 6, 7-tetrahydroxy-9H-xanthen-9-one binds to the ATP-binding pocket of glycogen synthase kinase 3β and inhibits its …
IR Mangangcha, RK Brojen Singh… - Journal of …, 2022 - Taylor & Francis
Abstract Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase which in the
presence of ATP in its ATP-binding pocket transfers a phosphate to a primed substrate …
presence of ATP in its ATP-binding pocket transfers a phosphate to a primed substrate …
β-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression
R Wang, D Tang, L Ou, J Jiang, Y Wu, X Tian - Human Cell, 2024 - Springer
To explore the effects of β-Sitosterol upon hepatocellular carcinoma cell proliferation,
apoptosis, migration, invasion, and epithelial–mesenchymal transition (EMT), and to …
apoptosis, migration, invasion, and epithelial–mesenchymal transition (EMT), and to …