[HTML][HTML] Endothelial nitric oxide synthase–deficient mice: A model of spontaneous cerebral small-vessel disease

FF Liao, G Lin, X Chen, L Chen, W Zheng… - The American Journal of …, 2021 - Elsevier
Age-related cerebral small-vessel disease (CSVD) is a major cause of stroke and dementia.
Despite a widespread acceptance of small-vessel arteriopathy, lacunar infarction, diffuse …

Cerebral small vessel disease: a review of the pathophysiological mechanisms

Y Hannawi - Translational Stroke Research, 2023 - Springer
Cerebral small vessel disease (cSVD) refers to the age-dependent pathological processes
involving the brain small vessels and leading to vascular cognitive impairment, intracerebral …

Cerebral small vessel disease (CSVD)–lessons from the animal models

M Mustapha, CMNCM Nassir, N Aminuddin… - Frontiers in …, 2019 - frontiersin.org
Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings
resulting from pathological processes of various etiologies affecting cerebral arterioles …

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

RM Rajani, S Quick, SR Ruigrok, D Graham… - Science translational …, 2018 - science.org
Dementia is a major social and economic problem for our aging population. One of the most
common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic …

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023 - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Cerebral small vessel disease: Pathological mechanisms and potential therapeutic targets

Y Gao, D Li, J Lin, AM Thomas, J Miao… - Frontiers in aging …, 2022 - frontiersin.org
Cerebral small vessel disease (CSVD) represents a diverse cluster of cerebrovascular
diseases primarily affecting small arteries, capillaries, arterioles and venules. The diagnosis …

Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease

PR Holland, JL Searcy, N Salvadores… - Journal of Cerebral …, 2015 - journals.sagepub.com
Cerebral small vessel disease (SVD) is a major cause of age-related cognitive impairment
and dementia. The pathophysiology of SVD is not well understood and is hampered by a …

Cerebral vascular dysfunctions detected in human small vessel disease and implications for preclinical studies

JM Wardlaw, H Benveniste… - Annual Review of …, 2022 - annualreviews.org
Cerebral small vessel disease (SVD) is highly prevalent and a common cause of ischemic
and hemorrhagic stroke and dementia, yet the pathophysiology is poorly understood. Its …

Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel …

D Kaiser, G Weise, K Möller, J Scheibe, C Pösel… - Acta neuropathologica …, 2014 - Springer
Introduction Cerebral small vessel disease (cSVD) is one of the most prevalent neurological
disorders. The progressive remodeling of brain microvessels due to arterial hypertension or …

[HTML][HTML] Deficiency of endothelial nitric oxide synthase (eNOS) exacerbates brain damage and cognitive deficit in a mouse model of vascular dementia

L An, Y Shen, M Chopp, A Zacharek, P Venkat… - Aging and …, 2021 - ncbi.nlm.nih.gov
Abstract Vascular Dementia (VaD) accounts for nearly 20% of all cases of dementia. eNOS
plays an important role in neurovascular remodeling, anti-inflammation, and cognitive …