Exosomes-based nanomedicine for neurodegenerative diseases: current insights and future challenges

A Cano, Á Muñoz-Morales, E Sánchez-López… - Pharmaceutics, 2023 - mdpi.com
Neurodegenerative diseases constitute a group of pathologies whose etiology remains
unknown in many cases, and there are no treatments that stop the progression of such …

Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

The application of exosomes and exosome-nanoparticle in treating brain disorders

S Salarpour, M Barani, A Pardakhty, M Khatami… - Journal of Molecular …, 2022 - Elsevier
Brain-derived exosomes (BDEs) are extracellular nanovesicles released by all central
nervous system cell lineages and contain cargo from the cells that produced them. In …

Exosome-based approaches in the management of Alzheimer's disease

R Kandimalla, M Saeed, N Tyagi, RC Gupta… - … & Biobehavioral Reviews, 2023 - Elsevier
Alzheimer's disease (AD) has been the most extensively studied neurological disorders that
affects millions of individuals globally and is associated with misfolding of proteins in the …

Physiological and pathological roles of exosomes in the nervous system

K Yuyama, Y Igarashi - Biomolecular concepts, 2016 - degruyter.com
Exosomes represent a subtype of extracellular nanovesicles that are generated from the
luminal budding of limiting endosomal membranes and subsequent exocytosis. They …

Exosomes as a potential novel therapeutic tools against neurodegenerative diseases

A Jarmalavičiūtė, A Pivoriūnas - Pharmacological research, 2016 - Elsevier
Exosomes are extracellular vesicles that can transfer biological information over long
distances affecting normal and pathological processes throughout organism. It is known that …

Diagnostic and therapeutic potential of exosomes in neurodegenerative diseases

P Gao, X Li, X Du, S Liu, Y Xu - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
Neurodegenerative diseases are closely related to brain function and the progression of the
diseases are irreversible. Due to brain tissue being not easy to acquire, the study of the …

Perspective insights of exosomes in neurodegenerative diseases: a critical appraisal

AT Jan, MA Malik, S Rahman, HR Yeo… - Frontiers in aging …, 2017 - frontiersin.org
Exosomes are small membranous entities of endocytic origin. Their production by a wide
variety of cells in eukaryotes implicates their roles in the execution of essential processes …

Stem cell-derived exosomes as therapeutic approach for neurodegenerative disorders: from biology to biotechnology

RP Araldi, F D'Amelio, H Vigerelli, TC de Melo, I Kerkis - Cells, 2020 - mdpi.com
The aging population has contributed to the rapid rise in the global incidence of
neurodegenerative diseases. Despite the medical advances, there are no effective …

Exosomes: origins and therapeutic potential for neurodegenerative disease

DK Sarko, CE McKinney - Frontiers in neuroscience, 2017 - frontiersin.org
Exosomes, small lipid bilayer vesicles, are part of the transportable cell secretome that can
be taken up by nearby recipient cells or can travel through the bloodstream to cells in distant …