Harnessing nanoparticles for the efficient delivery of the CRISPR/Cas9 system

H Rahimi, M Salehiabar, J Charmi, M Barsbay… - Nano Today, 2020 - Elsevier
Exploiting bacterial DNA-acting enzymes and expanding their repertoire for genome
engineering have been major technological and conceptual advances in molecular biology …

A CRISPR/Cas9 based polymeric nanoparticles to treat/inhibit microbial infections

R Verma, R Sahu, DD Singh, TE Egbo - Seminars in cell & developmental …, 2019 - Elsevier
The latest breakthrough towards the adequate and decisive methods of gene editing tools
provided by CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic …

Nanoparticles-mediated CRISPR/Cas9 delivery: recent advances in cancer treatment

S Aghamiri, S Talaei, AA Ghavidel, F Zandsalimi… - Journal of Drug Delivery …, 2020 - Elsevier
Clustered regularly interspaced short palindromic repeat-CRISPR-associated protein
(CRISPR-Cas) genome-editing systems, prokaryotic adaptive immune system, have been …

Split Cas9, not hairs− advancing the therapeutic index of CRISPR technology

C Schmelas, D Grimm - Biotechnology Journal, 2018 - Wiley Online Library
The discovery that the bacterial CRISPR/Cas9 system can be translated into mammalian
cells continues to have an unprecedented impact on the biomedical research community, as …

Nanoparticle-based delivery of CRISPR/Cas9 genome-editing therapeutics

BE Givens, YW Naguib, SM Geary, EJ Devor… - The AAPS journal, 2018 - Springer
The recent progress in harnessing the efficient and precise method of DNA editing provided
by CRISPR/Cas9 is one of the most promising major advances in the field of gene therapy …

Strategies for nonviral nanoparticle‐based delivery of CRISPR/Cas9 therapeutics

F Chen, M Alphonse, Q Liu - Wiley Interdisciplinary Reviews …, 2020 - Wiley Online Library
CRISPR‐based genome editing technology has become an important potential therapeutic
tool for various diseases. A vital challenge is to reach a safe, efficient, and clinically suitable …

[HTML][HTML] Nanoparticle delivery of CRISPR/Cas9 for genome editing

L Duan, K Ouyang, X Xu, L Xu, C Wen, X Zhou… - Frontiers in …, 2021 - frontiersin.org
The emerging clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-
associated system (Cas) gene-editing system represents a promising tool for genome …

[HTML][HTML] Stimulus-responsive smart nanoparticles-based CRISPR-cas delivery for therapeutic genome editing

M Naeem, MZ Hoque, M Ovais, C Basheer… - International Journal of …, 2021 - mdpi.com
The innovative research in genome editing domains such as CRISPR-Cas technology has
enabled genetic engineers to manipulate the genomes of living organisms effectively in …

Key considerations in designing CRISPR/Cas9-carrying nanoparticles for therapeutic genome editing

Y Xu, R Liu, Z Dai - Nanoscale, 2020 - pubs.rsc.org
CRISPR-Cas9, the breakthrough genome-editing technology, has emerged as a promising
tool to prevent and cure various diseases. The efficient genome editing technology strongly …

[HTML][HTML] Principles of CRISPR-Cas9 technology: advancements in genome editing and emerging trends in drug delivery

AAA Aljabali, M El-Tanani, MM Tambuwala - Journal of Drug Delivery …, 2024 - Elsevier
The rapid advancement of CRISPR-Cas9 technology has instigated a profound
transformation in genome editing with significant implications for fields like health …