Pharmacological activation and inhibition of Slack (Slo2. 2) channels

B Yang, VK Gribkoff, J Pan, V Damagnez… - …, 2006 - Elsevier
The Slack (Sequence like a calcium-activated K channel)(Slo2. 2) gene is abundantly
expressed in the mammalian brain and encodes a sodium-activated K+ (KNa) channel …

Localization of the Slack potassium channel in the rat central nervous system

A Bhattacharjee, L Gan… - Journal of Comparative …, 2002 - Wiley Online Library
The Slack gene encodes a voltage‐dependent K+ channel that has a unitary conductance
of∼ 60 pS. Evidence from heterologous expression studies suggests that Slack channel …

Slack, slick, and sodium‐activated potassium channels

LK Kaczmarek - International scholarly research notices, 2013 - Wiley Online Library
The Slack and Slick genes encode potassium channels that are very widely expressed in
the central nervous system. These channels are activated by elevations in intracellular …

The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis

VA Ruffin, XQ Gu, D Zhou, RM Douglas, X Sun… - Neuroscience, 2008 - Elsevier
Slack (Slo 2.2), a member of the Slo potassium channel family, is activated by both voltage
and cytosolic factors, such as Na+ ([Na+] i) and Cl−([Cl−] i). Since the Slo family is known to …

The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels

H Chen, J Kronengold, Y Yan, VR Gazula… - Journal of …, 2009 - Soc Neuroscience
Potassium channels activated by intracellular Na+ ions (K Na) play several distinct roles in
regulating the firing patterns of neurons, and, at the single channel level, their properties are …

Amino‐termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation

MR Brown, J Kronengold, VR Gazula… - The Journal of …, 2008 - Wiley Online Library
The rates of activation and unitary properties of Na+‐activated K+ (KNa) currents have been
found to vary substantially in different types of neurones. One class of KNa channels is …

The antipsychotic drug loxapine is an opener of the sodium-activated potassium channel slack (Slo2. 2)

B Biton, S Sethuramanujam, KE Picchione… - … of Pharmacology and …, 2012 - ASPET
Sodium-activated potassium (KNa) channels have been suggested to set the resting
potential, to modulate slow after-hyperpolarizations, and to control bursting behavior or …

VU0606170, a selective slack channels inhibitor, decreases calcium oscillations in cultured cortical neurons

BD Spitznagel, NM Mishra, AM Qunies… - ACS Chemical …, 2020 - ACS Publications
Malignant migrating partial seizures of infancy is a rare, devastating form of epilepsy most
commonly associated with gain-of-function mutations in the potassium channel, Slack. Not …

Differential distribution of the sodium‐activated potassium channels slick and slack in mouse brain

S Rizzi, HG Knaus, C Schwarzer - Journal of Comparative …, 2016 - Wiley Online Library
The sodium‐activated potassium channels Slick (Slo2. 1, KCNT2) and Slack (Slo2. 2,
KCNT1) are high‐conductance potassium channels of the Slo family. In neurons, Slick and …

Opposite regulation of Slick and Slack K+ channels by neuromodulators

CM Santi, G Ferreira, B Yang, VR Gazula… - Journal of …, 2006 - Soc Neuroscience
Slick (Slo2. 1) and Slack (Slo2. 2) are two novel members of the mammalian Slo potassium
channel gene family that may contribute to the resting potentials of cells and control their …