[PDF][PDF] PD-1-expressing SARS-CoV-2-specific CD8+ T cells are not exhausted, but functional in patients with COVID-19

MS Rha, HW Jeong, JH Ko, SJ Choi, IH Seo, JS Lee… - Immunity, 2021 - cell.com
Memory T cell responses have been demonstrated in COVID-19 convalescents, but ex vivo
phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2 …

SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells

JH Jung, MS Rha, M Sa, HK Choi, JH Jeon… - Nature …, 2021 - nature.com
Memory T cells contribute to rapid viral clearance during re-infection, but the longevity and
differentiation of SARS-CoV-2-specific memory T cells remain unclear. Here we conduct ex …

Activation or exhaustion of CD8+ T cells in patients with COVID-19

MS Rha, EC Shin - Cellular & molecular immunology, 2021 - nature.com
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …

Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells

I Schulien, J Kemming, V Oberhardt, K Wild… - Nature medicine, 2021 - nature.com
Emerging data indicate that SARS-CoV-2-specific CD8+ T cells targeting different viral
proteins are detectable in up to 70% of convalescent individuals,,,–. However, very little …

[PDF][PDF] Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19

BJ Meckiff, C Ramírez-Suástegui, V Fajardo, SJ Chee… - Cell, 2020 - cell.com
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …

[PDF][PDF] Low-avidity CD4+ T cell responses to SARS-CoV-2 in unexposed individuals and humans with severe COVID-19

P Bacher, E Rosati, D Esser, GR Martini, C Saggau… - Immunity, 2020 - cell.com
CD4+ T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and
these are suggested to arise in response to common cold coronavirus (CCCoV) infection …

Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

Z Wang, X Yang, J Zhong, Y Zhou, Z Tang… - Nature …, 2021 - nature.com
T-cell immunity is important for recovery from COVID-19 and provides heightened immunity
for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in …

SARS‐CoV‐2‐reactive interferon‐γ‐producing CD8+ T cells in patients hospitalized with coronavirus disease 2019

E Gimenez, E Albert, I Torres… - Journal of medical …, 2021 - Wiley Online Library
There is limited information on severe acute respiratory syndrome coronavirus 2 (SARS‐
CoV‐2) T‐cell immune responses in patients with coronavirus disease 2019 (COVID‐19) …

SARS-CoV-2 epitope–specific CD4+ memory T cell responses across COVID-19 disease severity and antibody durability

RW Nelson, Y Chen, OL Venezia, RM Majerus… - Science …, 2022 - science.org
CD4+ T cells are central to long-term immunity against viruses through the functions of T
helper 1 (TH1) and T follicular helper (TFH) cell subsets. To better understand the role of …

Durability of SARS-CoV-2–specific T-cell responses at 12 months postinfection

Z Lu, ED Laing, J Pena DaMata… - The Journal of …, 2021 - academic.oup.com
Background Characterizing the longevity and quality of cellular immune responses to severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enhances understanding of …