Leading a mentally stimulating life may build up a reserve of neural and mental resources
that preserve cognitive abilities in late life. Recent autopsy evidence links neuronal density …

For decades, research into memory decline in human cognitive ageing has focused on
neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings …

The noradrenergic theory of Cognitive Reserve (Robertson, 2013–2014) postulates that the
upregulation of the locus coeruleus—noradrenergic system (LC–NA) originating in the …

The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity
varies considerably across healthy older individuals, and is suggested to contribute to …

Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …

Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC)
is important for later-life cognition. Less understood is how LC integrity relates to brain …

The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and
behavioral function, may play an important role healthy ageing and in neurodegenerative …

Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …

The locus coeruleus (LC), a tiny nucleus in the brainstem and the principal site of
noradrenaline synthesis, has a major role in regulating autonomic function, arousal …