Genetic analysis of CYP2C9 with reference to drug response in epilepsy patients of Pakistan
Epilepsy is a major global issue. Epilepsy patients are treated with AED (antiepileptic drugs).
Interindividual variability in drug response has been documented in several studies. The …
Interindividual variability in drug response has been documented in several studies. The …
Possible role of CYP2C9 & CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy
Methods: A total of 402 patients with epilepsy were enrolled in this study; 128 were drug
resistant and 274 were drug responsive. The peripheral blood samples of the patients with …
resistant and 274 were drug responsive. The peripheral blood samples of the patients with …
Genetic polymorphism of drug refractory epilepsy
Commentary associated with clobazam response14. The responder rate was significantly
greater in CYP2C19 poor metabolizers and CYP2C19 heterozygous extensive metabolizer …
greater in CYP2C19 poor metabolizers and CYP2C19 heterozygous extensive metabolizer …
CYP2C9 (*2&*3) and CYP2C19 (*2&*3) polymorphisms among children with nonlesional epilepsy: a single-center study
S Eltalal, M El Ayouty, A El-Said, Y Wahba - Acta Neurologica Belgica, 2021 - Springer
Cytochrome (CYP) P450 enzymes are responsible for metabolism of antiepileptic drugs
(AEDs), and encoded by highly polymorphic genes. A case–control study was conducted in …
(AEDs), and encoded by highly polymorphic genes. A case–control study was conducted in …
The effect of genetic polymorphisms of cytochrome P450 CYP2C9, CYP2C19, and CYP2D6 on drug-resistant epilepsy in Turkish children
Abstract Background and Objective Despite the availability of several antiepileptic drugs,
drug resistance remains one of the major challenges in epilepsy therapy. Genetic factors are …
drug resistance remains one of the major challenges in epilepsy therapy. Genetic factors are …
An association between the rs1799853 and rs1057910 polymorphisms of CYP2C9, the rs4244285 polymorphism of CYP2C19 and the prevalence rates of drug …
M Makowska, B Smolarz, M Bryś, E Forma… - International Journal …, 2021 - Taylor & Francis
Objective Epilepsy is a neurologically based disease. Literature data indicate a certain
association between the polymorphism of these genes, which participate in the metabolism …
association between the polymorphism of these genes, which participate in the metabolism …
[HTML][HTML] Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a …
BACKGROUND: In epilepsy, in spite of the best possible medications and treatment
protocols, approximately one-third of the patients do not respond adequately to anti-epileptic …
protocols, approximately one-third of the patients do not respond adequately to anti-epileptic …
The potential impact of CYP2D6 (* 2/* 4/* 10) gene variants among Egyptian epileptic children: a preliminary study
Abstract Background The cytochrome P450 (CYP) isoenzymes have an indispensable role
in the metabolic phase of different medications during the treatment of multiple …
in the metabolic phase of different medications during the treatment of multiple …
CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes andphenytoin adverse reactions correlation
CA Twardowschy, LC Werneck, RH Scola… - Arquivos de neuro …, 2011 - SciELO Brasil
OBJECTIVE: CYP2C9 is a major enzyme in human drug metabolism and the polymorphism
observed in the corresponding gene may affect therapeutic outcome during treatment. The …
observed in the corresponding gene may affect therapeutic outcome during treatment. The …
Influence of genetic variants of CYP2D6, CYP2C9, CYP2C19 and CYP3A4 on antiepileptic drug metabolism in pediatric patients with refractory epilepsy
MA López-García, IA Feria-Romero, H Serrano… - Pharmacological …, 2017 - Springer
Background Identified the polymorphisms of CYP2D6, CYP2C9, CYP2C19 and CYP3A4,
within a rigorously selected population of pediatric patients with drug-resistant epilepsy …
within a rigorously selected population of pediatric patients with drug-resistant epilepsy …
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