Context Our genome adapts to environmental influences, in part through epigenetic
mechanisms, including DNA methylation. Variations in the quality of the early environment …

Background Childhood abuse is associated with increased adult disease risk, suggesting
that processes acting over the long-term, such as epigenetic regulation of gene activity, may …

Childhood maltreatment is a key risk factor for poor mental and physical health. Recently,
variation in epigenetic processes, such as DNA methylation, has emerged as a potential …

Fine‐tuning of neuronal connections during development is regulated through
environmental interactions. Some fine‐tuning occurs through changes in gene expression …

Objective: DNA methylation has been proposed as an epigenetic mechanism by which early-
life experiences become “embedded” in the genome and alter transcriptional processes to …

Animal studies have identified persistent and functional effects of traumatic stress on the
epigenome. This review discusses the clinical evidence for trauma-induced changes in DNA …

Offspring of persons exposed to childhood abuse are at higher risk of neurodevelopmental
and physical health disparities across the life course. Animal experiments have indicated …

Early life stress in humans (ie maltreatment, violence exposure, loss of a loved one) and in
rodents (ie disrupted attachment or nesting, electric shock, restraint, predator odor) occurs …

Exposure to chronic stress, either repeated severe acute or moderate sustained stress, is
one of the strongest risk factors for the development of psychopathologies such as post …

Long-term molecular changes in the brain resulting from blast exposure may be mediated by
epigenetic changes, such as deoxyribonucleic acid (DNA) methylation, that regulate gene …